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FR900359
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Catalog No. T27387Cas No. 107530-18-7
Alias FR-900359, FR 900359
FR900359, a non-ribosomal cyclic peptide derived from the soil bacterium Chromobacterium oxysporum, is a macrocyclic Gq protein inhibitor that inhibits melanoma cell proliferation and can be used in studies of asthma, inflammation, and cancer.
FR900359
😃Good
Catalog No. T27387Alias FR-900359, FR 900359Cas No. 107530-18-7
FR900359, a non-ribosomal cyclic peptide derived from the soil bacterium Chromobacterium oxysporum, is a macrocyclic Gq protein inhibitor that inhibits melanoma cell proliferation and can be used in studies of asthma, inflammation, and cancer.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $668 | 35 days |
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Concentration:1.0 mg/mL
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Product Introduction
Bioactivity
Chemical Properties
| Description | FR900359, a non-ribosomal cyclic peptide derived from the soil bacterium Chromobacterium oxysporum, is a macrocyclic Gq protein inhibitor that inhibits melanoma cell proliferation and can be used in studies of asthma, inflammation, and cancer. |
| In vitro | FR900359 (0-10 μM; treated for 24 hours) effectively reduces the growth of B16 cells in a concentration-dependent manner, inhibiting cell proliferation and migration[1]. |
| In vivo | In isometric force measurements in the mouse tail artery, FR900359 (1.0 μM; post-wash) significantly reduces vascular tone[1]. |
| Alias | FR-900359, FR 900359 |
| Molecular Weight | 1002.16 |
| Formula | C49H75N7O15 |
| Cas No. | 107530-18-7 |
| Smiles | [C@@H](OC([C@@H](NC(CC)=O)[C@@H](C(C)C)O)=O)(C(C)C)[C@]1(C(=O)N(C)[C@@]([C@H](OC)C)(C(=O)O[C@H](C(C)C)[C@H](NC(C)=O)C(=O)O[C@H](CC2=CC=CC=C2)C(=O)N(C)C(=C)C(=O)N[C@@H](C)C(=O)N(C)[C@@H](C)C(=O)N1)[H])[H] |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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