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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $970 | 4-6 weeks | |
25 mg | $1,620 | 4-6 weeks | |
50 mg | $2,425 | 4-6 weeks |
Description | MAPK-IN-2 (compound 3h) is an efficacious MAPK inhibitor with antineoplastic properties that significantly hinders proliferation across various cancer cell lines. It demonstrates robust suppression of the MAPK pathway (EGFR WT IC50 = 281 nM, c-MET IC50 = 205 nM, B-RAF WT IC50 = 112 nM, CDK4/6 IC50 = 95 and 184 nM, respectively) and exhibits pronounced activity against mutated forms of EGFR and B-RAF (EGFR T790M IC50 = 69 nM and B-RAF V600E IC50 = 83 nM) [1]. |
Molecular Weight | 380.23 |
Formula | C20H11Cl2N3O |
Cas No. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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