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Dimethylcurcumin

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Purity:98.96%

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COA HPLC HNMR

Dimethylcurcumin

Catalog No. TQ0214Cas No. 52328-98-0

Dimethylcurcumin (ASC-J9) (ASC-J9) is an androgen receptor degradation enhancer. It effectively suppresses castration-resistant prostate cancer cell proliferation and invasion.

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Pack Size	Price	Availability	Quantity
20 mg	$130	In Stock
1 mL x 10 mM (in DMSO)	$54	In Stock

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Related Compound Libraries of "Dimethylcurcumin"

Product Introduction

Bioactivity

Description	Dimethylcurcumin (ASC-J9) (ASC-J9) is an androgen receptor degradation enhancer. It effectively suppresses castration-resistant prostate cancer cell proliferation and invasion.
In vitro	Dimethylcurcumin is able to degrade fAR and AR3 in a dose-dependent manner in various human PCa cells. Dimethylcurcumin can also effectively suppress AR-targeted genes in CWR22Rv1-fARKD cells. Dimethylcurcumin (5 or 10 μM) significantly suppresses the DHT-induced cell growth in all three PCa cell lines. Dimethylcurcumin suppresses AR-targeted genes and cell growth by the degradation of fAR and ectopic AR3 in C81 and C4-2 cells [1]. ASC-J9 reduces the AR aggregated AR-112Q in cells. Dimethylcurcumin suppresses the aggregation of AR-112Q in SBMA PC12/AR-112Q cells [2].
In vivo	Dimethylcurcumin (75 mg/kg, i.p.) degrades both fAR and AR3 in the xenografted tumors in vivo and ASC-J9-treated tumors have significantly decreased Ki67-positive cells [1]. Dimethylcurcumin (50 mg/kg every 48 h, i.p.) substantially ameliorates the SBMA symptoms in AR-97Q mice and ameliorates neuromuscular pathological findings [2]. ASC-J9-treated mice show significantly smaller prostate tumor sizes when compared with those receiving classic ADT/castration with little serum androgen [3].
Cell Research	For the cell survival assay, the PC12/AR-112Q and PC12/AR-10Q cells are cultured as described previously and incubated cells in the presence of 10 μg/mL doxycycline for 24 h. Then the cells are treated with a vehicle, 5 μM Dimethylcurcumin or 10 μM Dimethylcurcumin, along with 1 nM DHT, and determined cell viability using Trypan blue staining at specific time intervals [2].
Animal Research	CWR22Rv1 cells (1×10^6 cells per site) are injected into both anterior prostates of the castrated nude mice after 2 weeks of implantation. The mice were randomly divided into two groups (four mice/eight tumors each group) and either receive 75 mg/kg Dimethylcurcumin intraperitoneal injection or vehicle control every other day. After 4 weeks of treatment, all mice are killed to examine the tumor growth. Body weights and mice activity are measured weekly [1].
Alias	ASC-J9, GO-Y025

Chemical Properties

Molecular Weight	396.43
Formula	C23H24O6
Cas No.	52328-98-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 48 mg/mL (121.08 mM)

H2O: Insoluble

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5225 mL	12.6126 mL	25.2251 mL	126.1257 mL
5 mM	0.5045 mL	2.5225 mL	5.0450 mL	25.2251 mL
10 mM	0.2523 mL	1.2613 mL	2.5225 mL	12.6126 mL
20 mM	0.1261 mL	0.6306 mL	1.2613 mL	6.3063 mL
50 mM	0.0505 mL	0.2523 mL	0.5045 mL	2.5225 mL
100 mM	0.0252 mL	0.1261 mL	0.2523 mL	1.2613 mL

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