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PZ703b TFA
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Catalog No. T77913
PZ703b TFA, a Bcl-xl PROTAC degradation agent, promotes apoptosis and halts bladder cancer cell proliferation, making it a pertinent investigative compound for related oncological studies [1] [2].
PZ703b TFA
PZ703b TFA
😃Good
Catalog No. T77913
PZ703b TFA, a Bcl-xl PROTAC degradation agent, promotes apoptosis and halts bladder cancer cell proliferation, making it a pertinent investigative compound for related oncological studies [1] [2].
| Pack Size | Price | Availability | Quantity |
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| 5 mg | Inquiry | Backorder | |
| 50 mg | Inquiry | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | PZ703b TFA, a Bcl-xl PROTAC degradation agent, promotes apoptosis and halts bladder cancer cell proliferation, making it a pertinent investigative compound for related oncological studies [1] [2]. |
| In vitro | PZ703b (0-1 μM, 24 h) TFA synergistically enhances the anti-proliferative effects of Mivebresib against bladder cancer cells in a dose-responsive manner while inducing apoptosis through the mitochondrial pathway [1]. PZ703b (0-1 μM, 48 h) TFA also potently inhibits MOLT-4 and RS4;11 cell lines, with IC50 values of 15.9 and 11.3 nM, respectively [2]. At 10 nM over 48 hours, PZ703b TFA induces significant and sustained BCL-XL degradation, leading to caspase-3 mediated apoptosis in MOLT-4 cells [2]. |
| Molecular Weight | 1714.46 |
| Formula | C82H103ClF6N10O13S4 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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