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Hu7691
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Catalog No. T39899Cas No. 2360523-76-6
Hu7691 is an orally active, selective, and potent Akt inhibitor that targets Akt1, Akt2, and Akt3, while also inhibiting neuroblastoma cell proliferation and inducing their differentiation.
Hu7691
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Purity: 99.86%
Catalog No. T39899Cas No. 2360523-76-6
Hu7691 is an orally active, selective, and potent Akt inhibitor that targets Akt1, Akt2, and Akt3, while also inhibiting neuroblastoma cell proliferation and inducing their differentiation.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | Inquiry | 1-2 weeks | |
| 5 mg | Inquiry | 1-2 weeks |
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Purity:99.86%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Hu7691 is an orally active, selective, and potent Akt inhibitor that targets Akt1, Akt2, and Akt3, while also inhibiting neuroblastoma cell proliferation and inducing their differentiation. |
| Targets&IC50 | Akt3:28 nM, PKCη:629 nM, PKA:11 nM, p70 S6K:229 nM, ROCK1:354 nM, Akt2:97.5 nM, Akt1:4.0 nM, RSK1:756 nM |
| In vitro | Hu7691 exhibits anti-proliferative and neurogenic effects on various neuroblastoma cell lines. This includes neurite outgrowth, cell cycle arrest, and differentiation mRNA markers, further elucidating the differentiation-inducing effects of Hu7691[3]. |
| In vivo | For a repeated dose toxicity study of Hu7691 in male and female Sprague Dawley (SD) rats over 14 consecutive days, the results indicated the following dosages: male rats received daily doses of 12.5, 50, 100, and 150 mg/kg, while female rats received daily doses of 12.5, 25, 50, and 75 mg/kg. Toxicity assessment revealed potential target organs including the spleen, thymus, and gastrointestinal tract[2]. |
| Molecular Weight | 450.88 |
| Formula | C22H22ClF3N4O |
| Cas No. | 2360523-76-6 |
| Smiles | N(C(=O)C1=C(F)C=C(C=C1)C2=CC=NN2C)[C@H]3[C@@H](CCNC3)C4=CC(F)=C(F)C=C4.Cl |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (229.00 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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