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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | Inquiry | 1-2 weeks | |
5 mg | Inquiry | 1-2 weeks |
Description | Hu7691 is an orally active, selective, and potent Akt inhibitor that targets Akt1, Akt2, and Akt3, while also inhibiting neuroblastoma cell proliferation and inducing their differentiation. |
Targets&IC50 | Akt3:28 nM, RSK1:756 nM, ROCK1:354 nM, PKCη:629 nM, p70 S6K:229 nM, PKA:11 nM, Akt2:97.5 nM, Akt1:4.0 nM |
In vitro | Hu7691 exhibits anti-proliferative and neurogenic effects on various neuroblastoma cell lines. This includes neurite outgrowth, cell cycle arrest, and differentiation mRNA markers, further elucidating the differentiation-inducing effects of Hu7691[3]. |
In vivo | For a repeated dose toxicity study of Hu7691 in male and female Sprague Dawley (SD) rats over 14 consecutive days, the results indicated the following dosages: male rats received daily doses of 12.5, 50, 100, and 150 mg/kg, while female rats received daily doses of 12.5, 25, 50, and 75 mg/kg. Toxicity assessment revealed potential target organs including the spleen, thymus, and gastrointestinal tract[2]. |
Molecular Weight | 450.88 |
Formula | C22H22ClF3N4O |
Cas No. | 2360523-76-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 80 mg/mL (229.00 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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