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Hu7691 free base
Catalog No. T39733Cas No. 2241232-43-7
Hu7691 free base is an orally active, potent, and selective Akt inhibitor with anti-proliferative and neurogenic effects on various neuroblastoma cell lines. It inhibits Akt1, Akt2, and Akt3, and induces differentiation of neuroblastoma cells.
Hu7691 free base
Catalog No. T39733Cas No. 2241232-43-7
Hu7691 free base is an orally active, potent, and selective Akt inhibitor with anti-proliferative and neurogenic effects on various neuroblastoma cell lines. It inhibits Akt1, Akt2, and Akt3, and induces differentiation of neuroblastoma cells.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $293 | In Stock | |
| 5 mg | $722 | In Stock | |
| 10 mg | $987 | In Stock | |
| 25 mg | $1,520 | In Stock | |
| 50 mg | $1,980 | In Stock |
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CitedSelect Batch
Purity:98.89%
ee:97.96%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Hu7691 free base is an orally active, potent, and selective Akt inhibitor with anti-proliferative and neurogenic effects on various neuroblastoma cell lines. It inhibits Akt1, Akt2, and Akt3, and induces differentiation of neuroblastoma cells. |
| Targets&IC50 | PKA:11 nM, Akt2:97.5 nM (IC50), AKT1:4.0 nM, mTOR (p70S6K):229 nM, AKT2:97.5 nM, Akt1:4.0 nM (IC50), RSK1:756 nM (IC50), RSK1:756 nM, AKT3:28 nM, PKCη:629 nM, PKCη:629 nM (IC50), PKA:11 nM (IC50), ROCK1:354 nM, Akt3:28 nM (IC50), ROCK1:354 nM (IC50), p70 S6K:229 nM (IC50) |
| In vitro | In HaCaT cells, Hu7691 free base (2.25, 4.5, 9, 18, 36 μM; 24 hours) effectively induces a decrease in the phosphorylation level of Akt (S473)[1]. |
| In vivo | In Balb/c mice (nu/nu, female, 3-4 weeks old, 20-25 g), Hu7691 free base (12.5, 25, 50 mg/kg; oral; once daily for 22 days) exhibited dose-dependent inhibition of tumor growth[1]. |
| Molecular Weight | 414.423 |
| Formula | C22H21F3N4O |
| Cas No. | 2241232-43-7 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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