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AKT Kinase Inhibitor
AKT Kinase Inhibitor is an Akt inhibitor with antitumor activity that selectively inhibits cell proliferation in a dose-dependent manner.
Catalog No. T10276Cas No. 842148-40-7
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Purity:99.86%
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AKT Kinase Inhibitor
Catalog No. T10276Cas No. 842148-40-7
AKT Kinase Inhibitor is an Akt inhibitor with antitumor activity that selectively inhibits cell proliferation in a dose-dependent manner.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $138 | In Stock | |
| 5 mg | $347 | In Stock | |
| 10 mg | $596 | In Stock | |
| 25 mg | $933 | In Stock | |
| 50 mg | $1,250 | In Stock | |
| 100 mg | $1,690 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $379 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | AKT Kinase Inhibitor is an Akt inhibitor with antitumor activity that selectively inhibits cell proliferation in a dose-dependent manner. |
| In vitro | METHODS: The proliferative effect of cells expressing Trop-2 was observed by silencing or inhibiting Akt with specific drugs. RESULTS The proliferative effect of cells expressing Trop-2 was significantly reduced in a dose-dependent manner.[1] |
| In vivo | METHODS: In an animal model, subcutaneously injected Trop-2-expressing tumors were treated with specific drugs that inhibit Akt activity. RESULTS Tumor growth was significantly reduced and Akt played a central functional role in mediating Trop-2-dependent growth stimulation.[1] |
| Molecular Weight | 357.37 |
| Formula | C16H19N7O3 |
| Cas No. | 842148-40-7 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | H2O: < 0.1 mg/mL (insoluble) DMSO: 16.67 mg/mL (46.65 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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