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PI3K/Akt/mTOR-IN-2 is a potent PI3K/AKT/mTOR inhibitor with anticancer effects and selectivity for MDA-MB-231 cells (IC50 2.29 μM). It induces cell cycle arrest and apoptosis in cancer cells.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $33 | In Stock | |
5 mg | $76 | In Stock | |
10 mg | $133 | In Stock | |
25 mg | $283 | In Stock | |
50 mg | $455 | In Stock | |
100 mg | $669 | In Stock | |
500 mg | $1,420 | In Stock | |
1 mL x 10 mM (in DMSO) | $84 | In Stock |
Description | PI3K/Akt/mTOR-IN-2 is a potent PI3K/AKT/mTOR inhibitor with anticancer effects and selectivity for MDA-MB-231 cells (IC50 2.29 μM). It induces cell cycle arrest and apoptosis in cancer cells. |
Targets&IC50 | PI3K/AKT/mTOR:2.29 μM |
In vitro | PI3K/Akt/mTOR-IN-2 (compound 23) (0.5 - 100 μM; 72 h) demonstrates significant anti-cancer efficacy, with IC50 values between 2.29 and 24.63 μM, notably 2.29 μM in MDA-MB-231 cells.[1] It induces growth inhibition in MDA-MB-231 cells by causing cell cycle arrest at G0/G1 (1, 2, and 4 μM; 24 h), elicits dose- and time-dependent apoptosis (1, 2, and 4 μM; 24, 48, and 72 h), increases Bax expression and decreases Bcl-2 expression (1, 2, and 4 μM; 48 h), and triggers mitochondria-dependent apoptosis by disrupting mitochondrial membrane potential, increasing ROS, reducing GSH levels, and elevating intracellular Ca2+ (1, 2, and 4 μM; 24 h).[1] |
Molecular Weight | 285.29 |
Formula | C17H13F2NO |
Cas No. | 2757804-89-8 |
Smiles | Fc1cc(F)cc(c1)C1OCCc2c1[nH]c1ccccc21 |
Storage | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 55 mg/mL (192.79 mM), Sonication is recommended. ![]() | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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