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PI3K/Akt/mTOR-IN-2
🥰Excellent
Catalog No. T60564Cas No. 2757804-89-8
PI3K/Akt/mTOR-IN-2 is a potent PI3K/AKT/mTOR inhibitor with anticancer effects and selectivity for MDA-MB-231 cells (IC50 2.29 μM). It induces cell cycle arrest and apoptosis in cancer cells.
PI3K/Akt/mTOR-IN-2
🥰Excellent
Purity: 99.61%
Catalog No. T60564Cas No. 2757804-89-8
PI3K/Akt/mTOR-IN-2 is a potent PI3K/AKT/mTOR inhibitor with anticancer effects and selectivity for MDA-MB-231 cells (IC50 2.29 μM). It induces cell cycle arrest and apoptosis in cancer cells.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $33 | In Stock | |
| 5 mg | $76 | In Stock | |
| 10 mg | $133 | In Stock | |
| 25 mg | $283 | In Stock | |
| 50 mg | $455 | In Stock | |
| 100 mg | $669 | In Stock | |
| 500 mg | $1,420 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $84 | In Stock |
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Purity:99.61%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | PI3K/Akt/mTOR-IN-2 is a potent PI3K/AKT/mTOR inhibitor with anticancer effects and selectivity for MDA-MB-231 cells (IC50 2.29 μM). It induces cell cycle arrest and apoptosis in cancer cells. |
| Targets&IC50 | PI3K/AKT/mTOR:2.29 μM |
| In vitro | PI3K/Akt/mTOR-IN-2 (compound 23) (0.5 - 100 μM; 72 h) demonstrates significant anti-cancer efficacy, with IC50 values between 2.29 and 24.63 μM, notably 2.29 μM in MDA-MB-231 cells.[1] It induces growth inhibition in MDA-MB-231 cells by causing cell cycle arrest at G0/G1 (1, 2, and 4 μM; 24 h), elicits dose- and time-dependent apoptosis (1, 2, and 4 μM; 24, 48, and 72 h), increases Bax expression and decreases Bcl-2 expression (1, 2, and 4 μM; 48 h), and triggers mitochondria-dependent apoptosis by disrupting mitochondrial membrane potential, increasing ROS, reducing GSH levels, and elevating intracellular Ca2+ (1, 2, and 4 μM; 24 h).[1] |
| Molecular Weight | 285.29 |
| Formula | C17H13F2NO |
| Cas No. | 2757804-89-8 |
| Smiles | Fc1cc(F)cc(c1)C1OCCc2c1[nH]c1ccccc21 |
Storage & Solubility Information
| Storage | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 55 mg/mL (192.79 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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