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UCL-TRO-1938
🥰Excellent
Catalog No. T78092Cas No. 2919575-27-0
UCL-TRO-1938 is a subtype-selective PI3Kα allosteric activator with cardioprotective and neuroregenerative effects. UCL-TRO-1938 can induce cell proliferation and can be used to study diseases caused by abnormal PI3Kα metabolism.
UCL-TRO-1938
🥰Excellent
Purity: 99.95%
Catalog No. T78092Cas No. 2919575-27-0
UCL-TRO-1938 is a subtype-selective PI3Kα allosteric activator with cardioprotective and neuroregenerative effects. UCL-TRO-1938 can induce cell proliferation and can be used to study diseases caused by abnormal PI3Kα metabolism.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $123 | In Stock | |
| 10 mg | $197 | In Stock | |
| 25 mg | $413 | In Stock | |
| 50 mg | $662 | In Stock | |
| 100 mg | $1,060 | In Stock | |
| 200 mg | $1,420 | In Stock | |
| 1 mL x 10 mM (in DMSO) | Inquiry | In Stock |
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CitedSelect Batch
Purity:99.95%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | UCL-TRO-1938 is a subtype-selective PI3Kα allosteric activator with cardioprotective and neuroregenerative effects. UCL-TRO-1938 can induce cell proliferation and can be used to study diseases caused by abnormal PI3Kα metabolism. |
| In vitro | In PI3Kα-WT but not in PI3Kα-KO MEFs, 24h treatment with UCL-TRO-1938 dose-dependently increased metabolic activity, with an EC50 of ~0.5 μM, and a decrease in ATP levels in both PI3Kα-WT and PI3Kα-KO MEFs at concentrations >7.5 μM, indicative of PI3Kα-independent effects of UCL-TRO-1938 at these doses. [1] |
| In vivo | Male C57/BL6 mice weighing 25-30 g were used throughout. 10 mg/kg UCL-TRO-1938 compound in DMSO. UCL-TRO-1938 provided significant cardioprotection in an in vivo IRI model in mice, with a corresponding pAKTS473 increase in the hearts. [1] |
| Molecular Weight | 456.58 |
| Formula | C27H32N6O |
| Cas No. | 2919575-27-0 |
| Smiles | O=C(N1C=2C(=CC=CC2CC1)NC=3C=CN=C(C3)NC4=CC=C(C=C4)N5CCN(CC)CC5)C |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 40 mg/mL (87.61 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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