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UCL-TRO-1938

🥰Excellent
Catalog No. T78092Cas No. 2919575-27-0

UCL-TRO-1938 is a subtype-selective PI3Kα allosteric activator with cardioprotective and neuroregenerative effects. UCL-TRO-1938 can induce cell proliferation and can be used to study diseases caused by abnormal PI3Kα metabolism.

UCL-TRO-1938

UCL-TRO-1938

🥰Excellent
Purity: 99.95%
Catalog No. T78092Cas No. 2919575-27-0
UCL-TRO-1938 is a subtype-selective PI3Kα allosteric activator with cardioprotective and neuroregenerative effects. UCL-TRO-1938 can induce cell proliferation and can be used to study diseases caused by abnormal PI3Kα metabolism.
Pack SizePriceAvailabilityQuantity
5 mg$123 In Stock
10 mg$197 In Stock
25 mg$413 In Stock
50 mg$662 In Stock
100 mg$1,060 In Stock
200 mg$1,420 In Stock
1 mL x 10 mM (in DMSO)$123 In Stock
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Purity:99.95%
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Product Introduction

Bioactivity
Description
UCL-TRO-1938 is a subtype-selective PI3Kα allosteric activator with cardioprotective and neuroregenerative effects. UCL-TRO-1938 can induce cell proliferation and can be used to study diseases caused by abnormal PI3Kα metabolism.
In vitro
In PI3Kα-WT but not in PI3Kα-KO MEFs, 24h treatment with UCL-TRO-1938 dose-dependently increased metabolic activity, with an EC50 of ~0.5 μM, and a decrease in ATP levels in both PI3Kα-WT and PI3Kα-KO MEFs at concentrations >7.5 μM, indicative of PI3Kα-independent effects of UCL-TRO-1938 at these doses. [1]
In vivo
Male C57/BL6 mice weighing 25-30 g were used throughout. 10 mg/kg UCL-TRO-1938 compound in DMSO. UCL-TRO-1938 provided significant cardioprotection in an in vivo IRI model in mice, with a corresponding pAKTS473 increase in the hearts. [1]
Chemical Properties
Molecular Weight456.58
FormulaC27H32N6O
Cas No.2919575-27-0
SmilesO=C(N1C=2C(=CC=CC2CC1)NC=3C=CN=C(C3)NC4=CC=C(C=C4)N5CCN(CC)CC5)C
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 40 mg/mL (87.61 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1902 mL10.9510 mL21.9020 mL109.5098 mL
5 mM0.4380 mL2.1902 mL4.3804 mL21.9020 mL
10 mM0.2190 mL1.0951 mL2.1902 mL10.9510 mL
20 mM0.1095 mL0.5475 mL1.0951 mL5.4755 mL
50 mM0.0438 mL0.2190 mL0.4380 mL2.1902 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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