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UCL-TRO-1938 is a subtype-selective PI3Kα allosteric activator with cardioprotective and neuroregenerative effects. UCL-TRO-1938 can induce cell proliferation and can be used to study diseases caused by abnormal PI3Kα metabolism.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $123 | In Stock | |
10 mg | $197 | In Stock | |
25 mg | $413 | In Stock | |
50 mg | $662 | In Stock | |
100 mg | $1,060 | In Stock | |
200 mg | $1,420 | In Stock | |
1 mL x 10 mM (in DMSO) | $123 | In Stock |
Description | UCL-TRO-1938 is a subtype-selective PI3Kα allosteric activator with cardioprotective and neuroregenerative effects. UCL-TRO-1938 can induce cell proliferation and can be used to study diseases caused by abnormal PI3Kα metabolism. |
In vitro | In PI3Kα-WT but not in PI3Kα-KO MEFs, 24h treatment with UCL-TRO-1938 dose-dependently increased metabolic activity, with an EC50 of ~0.5 μM, and a decrease in ATP levels in both PI3Kα-WT and PI3Kα-KO MEFs at concentrations >7.5 μM, indicative of PI3Kα-independent effects of UCL-TRO-1938 at these doses. [1] |
In vivo | Male C57/BL6 mice weighing 25-30 g were used throughout. 10 mg/kg UCL-TRO-1938 compound in DMSO. UCL-TRO-1938 provided significant cardioprotection in an in vivo IRI model in mice, with a corresponding pAKTS473 increase in the hearts. [1] |
Molecular Weight | 456.58 |
Formula | C27H32N6O |
Cas No. | 2919575-27-0 |
Smiles | O=C(N1C=2C(=CC=CC2CC1)NC=3C=CN=C(C3)NC4=CC=C(C=C4)N5CCN(CC)CC5)C |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 40 mg/mL (87.61 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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