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Prinaberel

Catalog No. TQ0149Cas No. 524684-52-4

Prinaberel (ERB-041) is an effective and selective ERβ agonist and >200-fold selective for ERβ.

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Pack Size	Price	Availability	Quantity
2 mg	$66	5 days
1 mL x 10 mM (in DMSO)	$145	5 days

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Product Introduction

Bioactivity

Description	Prinaberel (ERB-041) is an effective and selective ERβ agonist and >200-fold selective for ERβ.
In vitro	Treatment with ERβ selective estrogen agonists liquiritigenin and ERB-041 reduced the ability to invade a reconstituted basement membrane and to migrate in response to the cellular stimulus [1]. Pretreatment the PMs with ERB-041 resulted in significant inhibition of LPS-induced iNOS expression and NF-kappaB activation by preventing its nuclear translocation [3].
In vivo	Tumor numbers and volume were reduced by 60% and 84%, respectively, in the Erb-041-treated group as compared with UVB (alone) control. This inhibition in tumorigenesis was accompanied by a decrease in proliferating cell nuclear antigen (PCNA), cyclin D1, VEGF, and CD31, and an increase in apoptosis [2].
Alias	ERB 041

Chemical Properties

Molecular Weight	271.24
Formula	C15H10FNO3
Cas No.	524684-52-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 38 mg/mL (140.1 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6868 mL	18.4339 mL	36.8677 mL	184.3386 mL
5 mM	0.7374 mL	3.6868 mL	7.3735 mL	36.8677 mL
10 mM	0.3687 mL	1.8434 mL	3.6868 mL	18.4339 mL
20 mM	0.1843 mL	0.9217 mL	1.8434 mL	9.2169 mL
50 mM	0.0737 mL	0.3687 mL	0.7374 mL	3.6868 mL
100 mM	0.0369 mL	0.1843 mL	0.3687 mL	1.8434 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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