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Prinaberel

🥰Excellent
Catalog No. TQ0149Cas No. 524684-52-4
Alias WAY-202041, WAY202041, ERB041, ERB 041

Prinaberel (ERB 041) is a selective and potent estrogen receptor β (ERβ) agonist with anticancer activity that restores or increases ERβ expression and reduces cancer cell proliferation in mouse squamous cell carcinoma and human carcinoma cells. Prinaberel exhibits anti-inflammatory activity, inhibits the NFκB pro-inflammatory signaling pathway, and induces apoptosis of ovarian cancer cells. study endometriosis.

Prinaberel

Prinaberel

🥰Excellent
Catalog No. TQ0149Alias WAY-202041, WAY202041, ERB041, ERB 041Cas No. 524684-52-4
Prinaberel (ERB 041) is a selective and potent estrogen receptor β (ERβ) agonist with anticancer activity that restores or increases ERβ expression and reduces cancer cell proliferation in mouse squamous cell carcinoma and human carcinoma cells. Prinaberel exhibits anti-inflammatory activity, inhibits the NFκB pro-inflammatory signaling pathway, and induces apoptosis of ovarian cancer cells. study endometriosis.
Pack SizePriceAvailabilityQuantity
1 mg$33In Stock
5 mg$84In Stock
1 mL x 10 mM (in DMSO)$100In Stock
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Product Introduction

Bioactivity
Description
Prinaberel (ERB 041) is a selective and potent estrogen receptor β (ERβ) agonist with anticancer activity that restores or increases ERβ expression and reduces cancer cell proliferation in mouse squamous cell carcinoma and human carcinoma cells. Prinaberel exhibits anti-inflammatory activity, inhibits the NFκB pro-inflammatory signaling pathway, and induces apoptosis of ovarian cancer cells. study endometriosis.
Targets&IC50
ERα (rat):620 nM (IC50), ERβ (mouse):3.7 nM (IC50), ERα (mouse):750 nM (IC50), ERα (human):1200 nM (IC50), ERβ (human):5.4 nM (IC50), ERβ (rat):3.1 nM (IC50)
In vitro
Treatment of human squamous cell carcinoma (SCC) cells with Prinaberel (0-60 µM for 24 h) promoted cell differentiation, blocked the cell cycle, and reduced cell colony formation. In A431 cells, Prinaberel significantly decreased the expression of inflammation-regulating proteins such as p-NFκBp65, iNOS, and COX-2. Prinaberel inhibited the phosphorylation levels of PI3K and AKT, as well as enhanced the expression of E-cadherin, and reduced the migration ability of A431 cells. [2]
Prinaberel (0.01-10 µM) inhibited cell proliferation in a dose- and time-dependent manner.Prinaberel (10 µM, 48 h) induced apoptosis in ovarian cancer cells (SKOV-3 cells). [3]
In vivo
In the SKH-1 nude mouse model, Prinaberel (2 mg/mouse, topical application, 30 minutes prior to UVB irradiation, weekly for 30 weeks) inhibited the development of squamous cell carcinoma.Prinaberel inhibited cell proliferation and angiogenesis, while promoting apoptosis, in UVB-induced skin tumors.Prinaberel also inhibited UVB Prinaberel also inhibited the pro-inflammatory signaling pathway in UVB-induced skin tumors and reduced tumor invasiveness by modulating the PI3K-AKT pathway and the WNT signaling pathway. [2]
AliasWAY-202041, WAY202041, ERB041, ERB 041
Chemical Properties
Molecular Weight271.24
FormulaC15H10FNO3
Cas No.524684-52-4
SmilesFC=1C=C(C=CC1O)C2=NC3=CC(O)=CC(C=C)=C3O2
Relative Density.1.31g/cm3
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 30 mg/mL (110.6 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.6868 mL18.4339 mL36.8677 mL184.3386 mL
5 mM0.7374 mL3.6868 mL7.3735 mL36.8677 mL
10 mM0.3687 mL1.8434 mL3.6868 mL18.4339 mL
20 mM0.1843 mL0.9217 mL1.8434 mL9.2169 mL
50 mM0.0737 mL0.3687 mL0.7374 mL3.6868 mL
100 mM0.0369 mL0.1843 mL0.3687 mL1.8434 mL

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