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MBM-55 is an effective inhibitor of NIMA related kinase 2 (NEK2) with an IC50 of 1 nM. MBM-55 effectively inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $187 | In Stock | |
5 mg | $313 | In Stock | |
10 mg | $455 | In Stock | |
25 mg | $697 | In Stock | |
50 mg | $913 | In Stock | |
100 mg | $1,230 | In Stock | |
500 mg | $2,490 | In Stock | |
1 mL x 10 mM (in DMSO) | $343 | In Stock |
Description | MBM-55 is an effective inhibitor of NIMA related kinase 2 (NEK2) with an IC50 of 1 nM. MBM-55 effectively inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis. |
Targets&IC50 | RSK1:5.4 nM , Abl:20 nM , CDK4:441nM , DYRK1A:6.5 nM , Akt1:608 nM , CDK2:370 nM , Chk1:57 nM , GSK-3β:91 nM , Aurora A:5300 nM , NEK2:1 nM |
In vitro | MBM-55 (0.5-1 μM; 24 hours) induces G2/M phase arrest and accumulation of cells with >4N content in HCT-116 cells. MBM-55 (0.5-1 μM; 24 hours) causes cell apoptosis in a concentration-dependent manner in HCT-116 cells.MBM-55 inhibits MGC-803, HCT-116, Bel-7402 cells proliferation with IC50s of 0.53, 0.84, 7.13 μM, respectively[1]. |
In vivo | In female BALB/c nu/nu mice bearing HCT-116 xenografts, MBM-55 (20 mg/kg; i.p.) exhibits good antitumor activity and a well-tolerated dose schedule. MBM-55 (1.0 mg/kg; i.v.) shows the CL, Vss, T1/2, AUC0-t, and AUC0-∞ values of 33.3 mL/min/kg, 2.53 L/kg, 1.72 hours, 495 ng/h/mL and 507 ng/h/mL, respectively[1]. |
Molecular Weight | 498.55 |
Formula | C28H27FN6O2 |
Cas No. | 2083622-09-5 |
Smiles | CN(C)CCn1cc(cn1)-c1ccn2c(cnc2c1)-c1ccc(C(N)=O)c(OCc2cccc(F)c2)c1 |
Relative Density. | 1.29 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 120 mg/mL (240.70 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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