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TRIM24/BRPF1-IN-2
Catalog No. T74271Cas No. 3033288-68-2
TRIM24/BRPF1-IN-2 is a selective dual TRIM24/BRPF1 inhibitor with anticancer activity that inhibits proliferation, gene and protein expression, and colony formation of prostate cancer cells in a dose-dependent manner.
TRIM24/BRPF1-IN-2
Catalog No. T74271Cas No. 3033288-68-2
TRIM24/BRPF1-IN-2 is a selective dual TRIM24/BRPF1 inhibitor with anticancer activity that inhibits proliferation, gene and protein expression, and colony formation of prostate cancer cells in a dose-dependent manner.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $335 | In Stock | |
| 5 mg | $970 | In Stock | |
| 50 mg | Inquiry | In Stock |
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Purity:99.13%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | TRIM24/BRPF1-IN-2 is a selective dual TRIM24/BRPF1 inhibitor with anticancer activity that inhibits proliferation, gene and protein expression, and colony formation of prostate cancer cells in a dose-dependent manner. |
| Targets&IC50 | C4-2B cells:0.78 μM, 22Rv1 cells:0.82 μM, LNCaP cells:1.07 μM |
| In vitro | TRIM24/BRPF1-IN-2 significantly inhibited the growth of prostate cell lines (C4-2B, LNCaP, and 22Rv1) after treatment at concentrations of 0-10 μM for 48 h. The IC50 values were 0.78 μM, 1.07 μM, and 0.82 μM, respectively.TRIM24/BRPF1-IN-2 was also able to inhibit prostate cancer cells' gene and protein expression. In addition, TRIM24/BRPF1-IN-2 showed good Caco-2 permeability. [1] |
| In vivo | TRIM24/BRPF1-IN-2 administered once daily by intraperitoneal injection for 21 consecutive days at a dose of 50 mg/kg significantly inhibited tumor growth (TGI = 53%) and no significant toxicity was observed. [1] |
| Molecular Weight | 386.47 |
| Formula | C20H22N2O4S |
| Cas No. | 3033288-68-2 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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