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K67 competitively inhibits the interaction between Nrf2-ETGE and Keap1, inhibits the proliferation of HCC cells with high expression of S351 phosphorylated p62, and can be used to study cancer.
Pack Size | Price | Availability | Quantity |
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2 mg | $141 | In Stock |
Description | K67 competitively inhibits the interaction between Nrf2-ETGE and Keap1, inhibits the proliferation of HCC cells with high expression of S351 phosphorylated p62, and can be used to study cancer. |
In vitro | METHODS: Huh7 cells expressing S351E were treated with K67 (50 μM, 4 h), and the cells were treated with or without lactacystin (10 μM) for 8 hours. Immunoblot analyses were performed for immunosuppressants with anti-Nrf2 antibodies. RESULTS:Treatment of Huh1 cells with K67 greatly inhibited the interaction between p62 phosphorylation and Keap1, and K67 significantly promoted ubiquitination of Nrf2. [1] |
Alias | K-67, K 67 |
Molecular Weight | 582.69 |
Formula | C29H30N2O7S2 |
Cas No. | 2046250-48-8 |
Smiles | O=C(C)CC=1C=C(NS(=O)(=O)C2=CC=C(OCC)C=C2)C=3C=CC=CC3C1NS(=O)(=O)C4=CC=C(OCC)C=C4 |
Relative Density. | 1.357 g/cm3 (Predicted) |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 80 mg/mL(137.29 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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