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Perphenazine dihydrochloride
🥰Excellent
Catalog No. T63115Cas No. 2015-28-3
Perphenazine dihydrochloride is an orally active dopamine receptor and histamine-1 receptor antagonist that acts on D2 (Ki: 0.56 nM), D3 (Ki: 0.43 nM), and 5-HT2A (Ki: 0.6 nM) receptors, and also binds Alpha-1A adrenergic receptors. It can induce apoptosis, inhibit cancer cell proliferation, and is used to study psychiatric disorders, cancer, and inflammation.
Perphenazine dihydrochloride
🥰Excellent
Catalog No. T63115Cas No. 2015-28-3
Perphenazine dihydrochloride is an orally active dopamine receptor and histamine-1 receptor antagonist that acts on D2 (Ki: 0.56 nM), D3 (Ki: 0.43 nM), and 5-HT2A (Ki: 0.6 nM) receptors, and also binds Alpha-1A adrenergic receptors. It can induce apoptosis, inhibit cancer cell proliferation, and is used to study psychiatric disorders, cancer, and inflammation.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $293 | In Stock | |
| 5 mg | $722 | In Stock | |
| 10 mg | $987 | In Stock | |
| 25 mg | $1,520 | In Stock | |
| 50 mg | $1,980 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Perphenazine dihydrochloride is an orally active dopamine receptor and histamine-1 receptor antagonist that acts on D2 (Ki: 0.56 nM), D3 (Ki: 0.43 nM), and 5-HT2A (Ki: 0.6 nM) receptors, and also binds Alpha-1A adrenergic receptors. It can induce apoptosis, inhibit cancer cell proliferation, and is used to study psychiatric disorders, cancer, and inflammation. |
| Targets&IC50 | D3 Receptor:0.43 nM (Ki), D4 Receptor:28.5 nM (Ki), D2 Receptor:0.56 nM (Ki), 5-HT2A Receptor:5.6 nM (Ki), 5-HT6 Receptor:17 nM (Ki), 5-HT1A Receptor:421 nM (Ki), 5-HT2C Receptor:132 nM (Ki), 5-HT7 Receptor:23 nM (Ki) |
| In vitro | In L02 cells, Perphenazine dihydrochloride ( 10-100 μM ; 12,24,48 h ) could inhibit cell viability in a concentration and time-dependent manner[2]. |
| In vivo | In ICR mice, Perphenazine dihydrochloride ( 10, 30, 60, 120, 180 mg / kg ; oral gavage, every other day for 21 days ) increased histological injury and aminotransferases compared with control[2]. |
| Molecular Weight | 476.89 |
| Formula | C21H28Cl3N3OS |
| Cas No. | 2015-28-3 |
| Smiles | ClC1=CC=C2SC3=C(N(CCCN4CCN(CC4)CCO)C2=C1)C=CC=C3.Cl.Cl |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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