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BMS-599626 2HCL(714971-09-2 Free base)

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Catalog No. T2610L
Alias BMS-599626 2HCL(714971-09-2 Free base), BMS 599626 dihydrochloride, AC480 2HCl

BMS-599626 2HCL (AC480 2HCl) is a BMS-599626 derivative. BMS-599626 is an orally available and selective dual inhibitor of HER1 and HER2 with IC50s of 20 and 30 nM, respectively. BMS-599626 inhibits tumor cell proliferation and has the potential to increase tumor BMS-599626 inhibits tumor cell proliferation and has the potential to increase tumor response to radiotherapy.

BMS-599626 2HCL(714971-09-2 Free base)

BMS-599626 2HCL(714971-09-2 Free base)

🥰Excellent
Purity: 98%
Catalog No. T2610LAlias BMS-599626 2HCL(714971-09-2 Free base), BMS 599626 dihydrochloride, AC480 2HCl
BMS-599626 2HCL (AC480 2HCl) is a BMS-599626 derivative. BMS-599626 is an orally available and selective dual inhibitor of HER1 and HER2 with IC50s of 20 and 30 nM, respectively. BMS-599626 inhibits tumor cell proliferation and has the potential to increase tumor BMS-599626 inhibits tumor cell proliferation and has the potential to increase tumor response to radiotherapy.
Pack SizePriceAvailabilityQuantity
1 mg$86In Stock
5 mg$153In Stock
10 mg$298In Stock
25 mg$513In Stock
50 mg$743In Stock
100 mg$1,050In Stock
1 mL x 10 mM (in DMSO)$351In Stock
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Purity:98%
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Product Introduction

Bioactivity
Description
BMS-599626 2HCL (AC480 2HCl) is a BMS-599626 derivative. BMS-599626 is an orally available and selective dual inhibitor of HER1 and HER2 with IC50s of 20 and 30 nM, respectively. BMS-599626 inhibits tumor cell proliferation and has the potential to increase tumor BMS-599626 inhibits tumor cell proliferation and has the potential to increase tumor response to radiotherapy.
Targets&IC50
HER2:30 nM, HER1:20 nM, HER4:190 nM
In vitro
BMS-599626 is a potent HER inhibitor and has a higher inhibition ability than the other reported inhibitors. When tested with breast tumor cell lines (HCC202, HCC1942 and AU565) that highly expressed HER1 and HER2, BMS-599626 treatment inhibited cell proliferation, while having no effect on A2780 cells without HER1 or HER2 expression.[1]
Treated OV202 cells with BMS-599626 significantly inhibited cell proliferation and enhanced cell apoptosis by inhibiting HER.[3]
When tested with Sal2 cells expressing CD8-HER2 fusion protein, BMS-599626 treatment inhibited the receptor phosphorylation and MAPK phosphorylation with the IC50 value of 0.3 and 0.22 μM/L, respectively.[1]
In vivo
In mouse models with Sal2 tumor cells xenograft, oral administration of BMS-599626 inhibited Sal2 cells growth in a dose-dependent manner and significantly delayed tumor growth at the concentration of 60 mg/kg.[1]
AliasBMS-599626 2HCL(714971-09-2 Free base), BMS 599626 dihydrochloride, AC480 2HCl
Chemical Properties
Storage & Solubility Information
StorageShipping with blue ice.
Solubility Information
DMSO: 25 mg/mL (41.43 mM)

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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