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BMS-599626 2HCL (AC480 2HCl) is a BMS-599626 derivative. BMS-599626 is an orally available and selective dual inhibitor of HER1 and HER2 with IC50s of 20 and 30 nM, respectively. BMS-599626 inhibits tumor cell proliferation and has the potential to increase tumor BMS-599626 inhibits tumor cell proliferation and has the potential to increase tumor response to radiotherapy.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $86 | In Stock | |
5 mg | $153 | In Stock | |
10 mg | $298 | In Stock | |
25 mg | $513 | In Stock | |
50 mg | $743 | In Stock | |
100 mg | $1,050 | In Stock | |
1 mL x 10 mM (in DMSO) | $351 | In Stock |
Description | BMS-599626 2HCL (AC480 2HCl) is a BMS-599626 derivative. BMS-599626 is an orally available and selective dual inhibitor of HER1 and HER2 with IC50s of 20 and 30 nM, respectively. BMS-599626 inhibits tumor cell proliferation and has the potential to increase tumor BMS-599626 inhibits tumor cell proliferation and has the potential to increase tumor response to radiotherapy. |
Targets&IC50 | HER2:30 nM, HER1:20 nM, HER4:190 nM |
In vitro | BMS-599626 is a potent HER inhibitor and has a higher inhibition ability than the other reported inhibitors. When tested with breast tumor cell lines (HCC202, HCC1942 and AU565) that highly expressed HER1 and HER2, BMS-599626 treatment inhibited cell proliferation, while having no effect on A2780 cells without HER1 or HER2 expression.[1] Treated OV202 cells with BMS-599626 significantly inhibited cell proliferation and enhanced cell apoptosis by inhibiting HER.[3] When tested with Sal2 cells expressing CD8-HER2 fusion protein, BMS-599626 treatment inhibited the receptor phosphorylation and MAPK phosphorylation with the IC50 value of 0.3 and 0.22 μM/L, respectively.[1] |
In vivo | In mouse models with Sal2 tumor cells xenograft, oral administration of BMS-599626 inhibited Sal2 cells growth in a dose-dependent manner and significantly delayed tumor growth at the concentration of 60 mg/kg.[1] |
Alias | BMS-599626 2HCL(714971-09-2 Free base), BMS 599626 dihydrochloride, AC480 2HCl |
Storage | Shipping with blue ice. |
Solubility Information | DMSO: 25 mg/mL (41.43 mM) |
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