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Tucatinib

Tucatinib (ONT-380) is a potent and selective HER2 inhibitor (IC50: 8 nM).

Catalog No. T2364Cas No. 937263-43-9

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Purity:99.96%

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COA HPLC HNMR

Tucatinib

Catalog No. T2364Cas No. 937263-43-9

Tucatinib (ONT-380) is a potent and selective HER2 inhibitor (IC50: 8 nM).

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
2 mg	$30	In Stock
5 mg	$45	In Stock
10 mg	$72	In Stock
25 mg	$126	In Stock
50 mg	$197	In Stock
100 mg	$369	In Stock
500 mg	$869	In Stock
1 g	$1,190	In Stock
1 mL x 10 mM (in DMSO)	$79	In Stock

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Product Introduction

Bioactivity

Description	Tucatinib (ONT-380) is a potent and selective HER2 inhibitor (IC50: 8 nM).
Targets&IC50	ErbB2:8 nM
In vitro	Irbinitinib selectively binds to and inhibits the phosphorylation of ErbB-2, which may prevent the activation of ErbB-2 signal transduction pathways, resulting in growth inhibition and death of ErbB-2-expressing tumor cells.
In vivo	In vivo,Tucatinib significantly inhibits tumor growth in multiple HER2-dependent tumor xenograft models[2]. It shows excellent activity in numerous mouse tumor models including breast (BT-474, MDA-MB-453), ovarian (SKOV-3) and gastric (N87) carcinoma models. In the BT-474 model,Tucatinib demonstrated significant dose-related tumor growth inhibition (TGI; 50% at 50 mg/kg/d and 96% at 100 mg/kg/d) with numerous partial regressions (>50% reduction from baseline size)[1].
Alias	ARRY-380, Irbinitinib, ONT-380

Chemical Properties

Molecular Weight	480.52
Formula	C₂₆H₂₄N₈O₂
Cas No.	937263-43-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 45 mg/mL (93.65 mM)

Ethanol: 15 mg/mL (31.22 mM)

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0811 mL	10.4054 mL	20.8108 mL	104.0539 mL
5 mM	0.4162 mL	2.0811 mL	4.1622 mL	20.8108 mL
10 mM	0.2081 mL	1.0405 mL	2.0811 mL	10.4054 mL
20 mM	0.1041 mL	0.5203 mL	1.0405 mL	5.2027 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0416 mL	0.2081 mL	0.4162 mL	2.0811 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc