Shopping Cart

Remove All

Your shopping cart is currently empty

VU 0240551

Select Batch

Purity:99.72%

Resource Download

COA HNMR LCMS

VU 0240551

Catalog No. TQ0139Cas No. 893990-34-6

VU 0240551 is a selective antagonist of neuronal K-Cl cotransporter KCC2 inhibitor with an IC50 of 560 nM. VU 0240551 inhibits L-type calcium channels and hERG.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$43	In Stock
2 mg	$61	In Stock
5 mg	$97	In Stock
10 mg	$148	In Stock
25 mg	$313	In Stock
50 mg	$589	In Stock
100 mg	$848	In Stock
200 mg	$1,150	In Stock
500 mg	$1,690	In Stock
1 mL x 10 mM (in DMSO)	$112	In Stock

Bulk & Custom

Add to Cart

Questions

Related Compound Libraries of "VU 0240551"

Product Introduction

Bioactivity

Description	VU 0240551 is a selective antagonist of neuronal K-Cl cotransporter KCC2 inhibitor with an IC50 of 560 nM. VU 0240551 inhibits L-type calcium channels and hERG.
In vitro	VU 0240551 (0-100 μM) reduces the P cell response to GABA in a concentration-dependent manner and significantly reduces GABA-elicited hyperpolarization at doses of 75 and 100 μM[3].
In vivo	VU 0240551 (10 μM) significantly blocks the chloride influx in cells from euhydrated rats. VU 0240551 doesn't affect cells from Salt-loading rats[4].
Alias	N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide, VU0240551-2-D4

Chemical Properties

Molecular Weight	342.44
Formula	C16H14N4OS2
Cas No.	893990-34-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: Insoluble

DMSO: 45 mg/mL (131.41 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9202 mL	14.6011 mL	29.2022 mL	146.0110 mL
5 mM	0.5840 mL	2.9202 mL	5.8404 mL	29.2022 mL
10 mM	0.2920 mL	1.4601 mL	2.9202 mL	14.6011 mL
20 mM	0.1460 mL	0.7301 mL	1.4601 mL	7.3005 mL
50 mM	0.0584 mL	0.2920 mL	0.5840 mL	2.9202 mL
100 mM	0.0292 mL	0.1460 mL	0.2920 mL	1.4601 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc