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Alphitolic acid
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Catalog No. TN1379Cas No. 19533-92-7
Alias Aophitolic acid
Alphitolic acid, a terpenoid from Potentilla freyniana Bornm, is a selective 3-hydroxy-3-methylglutamic acid coenzyme-A synthase 2 (HMGCS2) inhibitor with anti-inflammatory and anticancer activity that inhibits T cell proliferation in a concentration-dependent manner. Alphitolic acid induces apoptosis and autophagy.
Alphitolic acid
😃Good
Catalog No. TN1379Alias Aophitolic acidCas No. 19533-92-7
Alphitolic acid, a terpenoid from Potentilla freyniana Bornm, is a selective 3-hydroxy-3-methylglutamic acid coenzyme-A synthase 2 (HMGCS2) inhibitor with anti-inflammatory and anticancer activity that inhibits T cell proliferation in a concentration-dependent manner. Alphitolic acid induces apoptosis and autophagy.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $728 | 7-10 days |
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Alphitolic acid, a terpenoid from Potentilla freyniana Bornm, is a selective 3-hydroxy-3-methylglutamic acid coenzyme-A synthase 2 (HMGCS2) inhibitor with anti-inflammatory and anticancer activity that inhibits T cell proliferation in a concentration-dependent manner. Alphitolic acid induces apoptosis and autophagy. |
| In vitro | METHODS: Alphitolic acid (10, 15, 20, 25, 30 μM, 72 hours) was used to treat three human OSCC cell lines (HSC-3, SCC2095 and SCC4 cells). The antiproliferative effects of the three cell lines were evaluated using the MTT method, cell apoptosis was detected by flow cytometry, and the expression of related proteins was detected by Western Blot. RESULTS: Alphitolic acid had a dose-dependent inhibitory effect on SCC4 and SCC2095, with IC50 values of 12 μM and 15 μM, respectively; it could inhibit the Akt/mTOR-NF-κB signaling axis and p53 activation in OSCC cells, induce cell apoptosis, and exert an antiproliferative effect. [1] METHODS: The bioactivity of Alphitolic acid on NO and TNF-α production induced by LPS + IFN-γ in RAW 264.7 cells was examined using Griess assay (NO, n = 8) and TNF-α (ELISA, n = 3). RESULTS: Alphitolic acid downregulated NO and TNF-α production in RAW 264.7 cells with IC50 values of 17.6 and 22.7 μM, respectively. [2] |
| Alias | Aophitolic acid |
| Molecular Weight | 472.7 |
| Formula | C30H48O4 |
| Cas No. | 19533-92-7 |
| Smiles | C(O)(=O)[C@]12[C@@]([C@@]3([C@@](C)(CC1)[C@@]4(C)[C@](CC3)([C@]5(C)[C@@](CC4)(C(C)(C)[C@@H](O)[C@H](O)C5)[H])[H])[H])([C@H](C(C)=C)CC2)[H] |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | keep away from direct sunlight | store at -20°C | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 40 mg/mL (84.62 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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