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AZ12672857

Catalog No. T9650 CAS 945396-55-4

AZ12672857 is an inhibitor of EphB4 with IC50 of 1.3 nM. AZ12672857 inhibits cell proliferation of Src transfected 3T3 cells with IC50 of 2 nM and autophosphorylation of EphB4 in transfected CHO-K1 cells with IC50 of 9 nM.

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AZ12672857, CAS 945396-55-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 132.00
5 mg	In stock	$ 328.00
10 mg	In stock	$ 563.00
25 mg	In stock	$ 891.00
50 mg	In stock	$ 1,230.00
100 mg	In stock	$ 1,670.00
500 mg	In stock	$ 3,350.00
1 mL * 10 mM (in DMSO)	In stock	$ 353.00

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Purity: 98.05%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	AZ12672857 is an inhibitor of EphB4 with IC50 of 1.3 nM. AZ12672857 inhibits cell proliferation of Src transfected 3T3 cells with IC50 of 2 nM and autophosphorylation of EphB4 in transfected CHO-K1 cells with IC50 of 9 nM.
In vitro	AZ12672857 shows IC50s of 240 nM and 58 nM for p-KDR in HUVEC and p-PDGFR-β in MG63 cell line. AZ12672857 moderately inhibits CYP P450 with IC50s of 5 μM for 2C9 and 3A4 and >10 μM for 1A4, 2D6 and 2C19[1].

Molecular Weight	486.57
Formula	C26H30N8O2
CAS No.	945396-55-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 20 mg/mL (41.1 mM), Sonication is recommended.

References and Literature

1. Bardelle C, et al. Inhibitors of the tyrosine kinase EphB4. Part 3: identification of non-benzodioxole-based kinase inhibitors. Bioorg Med Chem Lett. 2010;20(21):6242-6245.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Tyrosine Kinase Inhibitor Library Kinase Inhibitor Library Anti-Cancer Metabolism Compound Library Anti-Pancreatic Cancer Compound Library Bioactive Compound Library Bioactive Compounds Library Max Anti-Cancer Compound Library

Related Products

Related compounds with same targets

PD180970 PD173955 ENMD-2076 MNS HPK1-IN-2 PD-161570 Tofacitinib Src Inhibitor 3

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

AZ12672857 945396-55-4 Angiogenesis Tyrosine Kinase/Adaptors Src Ephrin Receptor AZ-12672857 AZ 12672857 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.