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Neuroprotective agent 1

🥰Excellent
Catalog No. T50107Cas No. 1878204-21-7

ethyl 2-[3,5-bis(trifluoromethyl)phenyl]-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate is a synthetic compound belonging to the curcumin family. It is involved in the regulation of immune response and inflammation through inhibition of the NF-κB signaling pathway, in the regulation of antioxidant response through activation of the Nrf2 signaling pathway, and in the regulation of cell survival and proliferation through inhibition of the Akt signaling pathway.

Neuroprotective agent 1

Neuroprotective agent 1

🥰Excellent
Purity: 99.85%
Catalog No. T50107Cas No. 1878204-21-7
ethyl 2-[3,5-bis(trifluoromethyl)phenyl]-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate is a synthetic compound belonging to the curcumin family. It is involved in the regulation of immune response and inflammation through inhibition of the NF-κB signaling pathway, in the regulation of antioxidant response through activation of the Nrf2 signaling pathway, and in the regulation of cell survival and proliferation through inhibition of the Akt signaling pathway.
Pack SizePriceAvailabilityQuantity
1 mg$130In Stock
5 mg$298In Stock
10 mg$435In Stock
25 mg$678In Stock
50 mg$912In Stock
100 mg$1,180In Stock
200 mg$1,580In Stock
1 mL x 10 mM (in DMSO)$317In Stock
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Purity:99.85%
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Product Introduction

Bioactivity
Description
ethyl 2-[3,5-bis(trifluoromethyl)phenyl]-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate is a synthetic compound belonging to the curcumin family. It is involved in the regulation of immune response and inflammation through inhibition of the NF-κB signaling pathway, in the regulation of antioxidant response through activation of the Nrf2 signaling pathway, and in the regulation of cell survival and proliferation through inhibition of the Akt signaling pathway.
Chemical Properties
Molecular Weight368.23
FormulaC14H10F6N2O3
Cas No.1878204-21-7
SmilesO=C1N(NC=C1C(OCC)=O)C2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2
Relative Density.1.479 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (135.78 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7157 mL13.5785 mL27.1569 mL135.7847 mL
5 mM0.5431 mL2.7157 mL5.4314 mL27.1569 mL
10 mM0.2716 mL1.3578 mL2.7157 mL13.5785 mL
20 mM0.1358 mL0.6789 mL1.3578 mL6.7892 mL
50 mM0.0543 mL0.2716 mL0.5431 mL2.7157 mL
100 mM0.0272 mL0.1358 mL0.2716 mL1.3578 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

ethyl 2[3,5bis(trifluoromethyl)phenyl]3oxo2,3dihydro1Hpyrazole4carboxylateethyl 2 [3,5 bis(trifluoromethyl)phenyl] 3 oxo 2,3 dihydro 1H pyrazole 4 carboxylate
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