Name: KDOAM-25 trihydrochloride
Brand: TargetMol
SKU: T62166
Rating: 4.5 (1 reviews)

KDOAM-25 trihydrochloride

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Catalog No. T62166

KDOAM-25 trihydrochloride is a potent and highly selective inhibitor of histone lysine demethylase 5 (KDM5), targeting KDM5A (IC50: 71 nM), KDM5B (IC50: 19 nM), KDM5C (IC50: 69 nM), and KDM5D (IC50: 69 nM). It enhances overall H3K4 methylation at the transcription start site and hinders the proliferation of multiple myeloma [MM1S cells].

KDOAM-25 trihydrochloride

😃Good

Catalog No. T62166

Pack Size	Price	Availability
25 mg	$1,520	10-14 weeks
50 mg	$1,980	10-14 weeks
100 mg	$2,500	10-14 weeks

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QDoes prolonged sonication affect the compound structure?

AIt is recommended to sonicate at a lower frequency

QCan inhibitors be used for cell experiments?

AYes, our inhibitors can be used for cell/in vitro experiments. However, some compounds may not have literature supporting their use in cell experiments. In such cases, we cannot guarantee efficacy.

Qwhat frequency should sonication be used?

AIt is recommended to use the conventional ultrasound cleaning frequency

QCan high-temperature sterilization be used for inhibitors?

AMost products are synthesized by chemical methods

QI need a total of 500 mg of the product for animal experiments, but it won't be used up all at once. How should I dissolve it?

ADetermining the amount based on solution clarity.1. If the prepared solution is clear, it can be prepared in a larger amount for one-time use and stored at 4°C. It is recommended to prepare the solution once a week, as prolonged storage may lead to loss of efficacy. 2. If the prepared solution is a suspension, it is recommended to prepare and use immediately each time.

Product Introduction

Bioactivity

Description

Chemical Properties

Molecular Weight	416.77
Formula	C₁₅H₂₈Cl₃N₅O₂

Storage & Solubility Information

Storage

Shipping with blue ice.

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.