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Bomedemstat ditosylate

Bomedemstat ditosylate
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Purity:99.05%
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Bomedemstat ditosylate

Catalog No. T70008Cas No. 1990504-72-7
Bomedemstat ditosylate (IMG-7289 ditosylate) is an orally active lysine-specific demethylase 1 (LSD1) inhibitor with antitumor activity that potentiates the response to PD-1 inhibition in a homozygous model of SCLC, inhibits cancer cell proliferation, and induces apoptosis. Bomedemstat ditosylate can be used to study myeloproliferative neoplasms and myelofibrosis.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$117In Stock
2 mg$169In Stock
5 mg$289In Stock
10 mg$479In Stock
25 mg$953In Stock
50 mg$1,530In Stock
100 mg$2,470In Stock
1 mL x 10 mM (in DMSO)$455In Stock
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Product Introduction

Bioactivity
Description
Bomedemstat ditosylate (IMG-7289 ditosylate) is an orally active lysine-specific demethylase 1 (LSD1) inhibitor with antitumor activity that potentiates the response to PD-1 inhibition in a homozygous model of SCLC, inhibits cancer cell proliferation, and induces apoptosis. Bomedemstat ditosylate can be used to study myeloproliferative neoplasms and myelofibrosis.
In vitro
Bomedemstat selectively inhibits proliferation and induces apoptosis of Jak2V617F cells by concomitantly increasing expression and methylation of p53;Bomedemstat (50 nM-1 μM; 96 h) enhances survival, induces apoptosis via BCL-XL and PUMA in a TP53-dependent manner, and leads to cell cycle arrest.[1]
In vivo
Bomedemstat treatment (oral gavage; 45 mg/kg; once daily; 56 d) normalizes or improves blood cell counts, reduces spleen volumes, restores normal splenic architecture, and reduces bone marrow fibrosis[1].
AliasMK-3543 ditosylate, IMG-7289 ditosylate
Chemical Properties
Molecular Weight864.02
FormulaC42H50FN7O8S2
Cas No.1990504-72-7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 80 mg/mL (92.59 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.1574 mL5.7869 mL11.5738 mL57.8690 mL
5 mM0.2315 mL1.1574 mL2.3148 mL11.5738 mL
10 mM0.1157 mL0.5787 mL1.1574 mL5.7869 mL
20 mM0.0579 mL0.2893 mL0.5787 mL2.8935 mL
50 mM0.0231 mL0.1157 mL0.2315 mL1.1574 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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