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AZA1
🥰Excellent
Catalog No. T61448Cas No. 1071098-42-4
Alias Rac1/Cdc42-IN-1
AZA1 (Rac1/Cdc42-IN-1) is a potent dual inhibitor of Rac1 and Cdc42. AZA1 induced apoptosis of prostate cancer cells and inhibited cell proliferation, migration and invasion.
AZA1
🥰Excellent
Purity: 98.59%
Catalog No. T61448Alias Rac1/Cdc42-IN-1Cas No. 1071098-42-4
AZA1 (Rac1/Cdc42-IN-1) is a potent dual inhibitor of Rac1 and Cdc42. AZA1 induced apoptosis of prostate cancer cells and inhibited cell proliferation, migration and invasion.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | 92 € | In Stock | |
| 5 mg | 234 € | In Stock | |
| 10 mg | 377 € | In Stock | |
| 25 mg | 629 € | In Stock | |
| 50 mg | 897 € | In Stock | |
| 100 mg | 1.216 € | In Stock | |
| 500 mg | 2.441 € | In Stock | |
| 1 mL x 10 mM (in DMSO) | 258 € | In Stock |
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CitedSelect Batch
Purity:98.59%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | AZA1 (Rac1/Cdc42-IN-1) is a potent dual inhibitor of Rac1 and Cdc42. AZA1 induced apoptosis of prostate cancer cells and inhibited cell proliferation, migration and invasion. |
| In vitro | AZA1 (Rac1/Cdc42-IN-1) (2-10 μM; 72 hours) impedes the proliferation of human 22Rv1 prostate cancer cells, diminishes phosphorylation of PAK1, AKT, and BAD in EGF-stimulated 22Rv1 cells (2-10 μM; 24 hours), and obstructs Rac1 and Cdc42-dependent cell cycle progression (10 μM; 24 hours). AZA1 also inhibits Rac1 and Cdc42-dependent migration of 22Rv1, DU 145, and PC-3 prostate cancer cells, impacting cell motility and actin reorganization through PAK1/2 phosphorylation suppression. |
| In vivo | AZA1 (Rac1/Cdc42-IN-1) (100 μg; i.p.; daily for 2 weeks) effectively suppresses human 22Rv1 xenograft growth in 5-week-old athymic nu/nu (nude) mice and improves survival, with a significant impact on tumor growth suppression.[1] |
| Alias | Rac1/Cdc42-IN-1 |
| Molecular Weight | 368.43 |
| Formula | C22H20N6 |
| Cas No. | 1071098-42-4 |
| Smiles | Cc1cc2cc(Nc3ccnc(Nc4ccc5[nH]c(C)cc5c4)n3)ccc2[nH]1 |
Storage & Solubility Information
| Storage | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 60 mg/mL (162.85 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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