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BI-9321 trihydrochloride
Catalog No. T10538LCas No. 2387510-87-2
Alias BI9321 trihydrochloride, BI9321 3HCl
BI-9321 trihydrochloride (BI9321 trihydrochloride) is a selective and potent NSD3-PWWP1 antagonist that downregulates Myc messenger RNA expression and reduces proliferation in MOLM-13 cells.
BI-9321 trihydrochloride
Catalog No. T10538LAlias BI9321 trihydrochloride, BI9321 3HClCas No. 2387510-87-2
BI-9321 trihydrochloride (BI9321 trihydrochloride) is a selective and potent NSD3-PWWP1 antagonist that downregulates Myc messenger RNA expression and reduces proliferation in MOLM-13 cells.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $45 | In Stock | |
| 5 mg | $106 | In Stock | |
| 10 mg | $189 | In Stock | |
| 25 mg | $372 | In Stock | |
| 50 mg | $629 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $117 | In Stock |
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Purity:99.96%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | BI-9321 trihydrochloride (BI9321 trihydrochloride) is a selective and potent NSD3-PWWP1 antagonist that downregulates Myc messenger RNA expression and reduces proliferation in MOLM-13 cells. |
| Targets&IC50 | U2OS cells:1.2 μM |
| In vitro | BI-9321 trihydrochloride specifically interfered with the interaction between the NSD3-PWWP1 structural domain and histones, with an IC50=1.2 μM in U2OS cells. BI-9321 trihydrochloride targeted the methyl lysine binding site of the PWWP1 structural domain and effectively bound its intracellular target at 1 µM concentration. In addition, BI-9321 trihydrochloride significantly down-regulated the expression of Myc mRNA and reduced the proliferation of MOLM-13 cells. [1] |
| Alias | BI9321 trihydrochloride, BI9321 3HCl |
| Molecular Weight | 469.81 |
| Formula | C22H24Cl3FN4 |
| Cas No. | 2387510-87-2 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 20 mg/mL(42.57 mM), Sonication is recommended. DMSO: 200 mg/mL(425.70 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
H2O/DMSO
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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