Shopping Cart
- Remove All
![TargetMol](https://www.targetmol.com/storage/error/oops.webp)
Your shopping cart is currently empty
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $72 | In Stock | |
5 mg | $198 | In Stock | |
10 mg | $322 | In Stock | |
25 mg | $572 | In Stock | |
50 mg | $815 | In Stock | |
100 mg | $1,080 | In Stock | |
1 mL x 10 mM (in DMSO) | $297 | In Stock |
Description | L-161982 is a selective antagonist of EP4 receptor. L-161982 could inhibit PGE2-induced ERK phosphorylation and cell proliferation of HCA-7 cells. L-161982 could alleviate collagen-induced arthritis in mice. |
In vitro | In squamous carcinoma Tca8113 cells, L-161982 induces apoptosis and cell cycle arrest, and inhibits prostaglandin E2-induced proliferation [2]. L-161982 (10 μM) blocks PGE2-stimulated cell proliferation of HCA-7 cells and ERK phosphorylation[3]. |
In vivo | In collagen-induced arthritis (CIA) mice model, L-161982 (5 mg/kg; i.p.) reduces arthritis lesions and lesion progression. L-161982 shows less joint swelling and lower arthritis score after 35 days post immunization[1]. |
Molecular Weight | 654.72 |
Formula | C32H29F3N4O4S2 |
Cas No. | 147776-06-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||
Solubility Information | DMSO: 9 mg/mL (13.75 mM) ![]() | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
|
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.