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p-Hydroxycinnamic acid
🥰Excellent
Catalog No. T7053Cas No. 7400-08-0
Alias p-Hydroxy-cinnamic acid, p-Cumaric acid, p-Coumaric acid, NSC 59260
p-Hydroxycinnamic acid (NSC-59260) can inhibit platelet activity, with IC50s of 371 μM, 126 μM for thromboxane B2 production and lipopolysaccharide-induced prostaglandin E2 generation, respectively.
p-Hydroxycinnamic acid
🥰Excellent
Purity: 99.55%
Catalog No. T7053Alias p-Hydroxy-cinnamic acid, p-Cumaric acid, p-Coumaric acid, NSC 59260Cas No. 7400-08-0
p-Hydroxycinnamic acid (NSC-59260) can inhibit platelet activity, with IC50s of 371 μM, 126 μM for thromboxane B2 production and lipopolysaccharide-induced prostaglandin E2 generation, respectively.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 g | $29 | In Stock |
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Purity:99.55%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | p-Hydroxycinnamic acid (NSC-59260) can inhibit platelet activity, with IC50s of 371 μM, 126 μM for thromboxane B2 production and lipopolysaccharide-induced prostaglandin E2 generation, respectively. |
| Targets&IC50 | Prostaglandin E2:126 μM, TXB2:371 μM |
| In vitro | p-Hydroxycinnamic acid (500 μM and 1 mM) reduces ADP-induced platelet aggregation (55?2 (SE 4?01) % and 35?6 (SE 2?35) % relative to the basal level, respectively). p-Hydroxycinnamic acid is able to modify platelet function, a shear-inducing device that simulates primary hemostasis. p-Hydroxycinnamic acid interferes also with arachidonic acid cascade, reducing thromboxane B2 production and lipopolysaccharide-induced prostaglandin E2 generation (IC50 371 and 126 μM, respectively)[1]. |
| Alias | p-Hydroxy-cinnamic acid, p-Cumaric acid, p-Coumaric acid, NSC 59260 |
| Molecular Weight | 164.16 |
| Formula | C9H8O3 |
| Cas No. | 7400-08-0 |
| Smiles | C(=CC(O)=O)C1=CC=C(O)C=C1 |
| Relative Density. | 1.329 g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 6.25 mg/mL (38.07 mM), Sonication is recommended.  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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