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F13714 fumarate

Catalog No. T37622Cas No. 208109-39-1

F13714 fumarate, a selective biased agonist of the 5-HT1A receptor, exhibits antidepressant-like effects upon single administration in the mouse model of chronic mild stress[1].

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Pack Size	Price	Availability
25 mg	$766	6-8 weeks
50 mg	$995	6-8 weeks
100 mg	$1,590	6-8 weeks

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Product Introduction

Bioactivity

Description	F13714 fumarate, a selective biased agonist of the 5-HT1A receptor, exhibits antidepressant-like effects upon single administration in the mouse model of chronic mild stress[1].
In vitro	F13714 targets 5-HT1A autoreceptors[1].
In vivo	In UCMS mice, F13714 administered at doses ranging from 4-16 mg/kg effectively alleviates depressive-like behavior as demonstrated in the forced swim test (FST), additionally restoring normal levels of p-ERK1/2 in the cortex and hippocampus without affecting p-CREB levels[1]. It significantly reduces immobility by 30.3% and 19.5% at 2 and 4 mg/kg doses, respectively[1]. At lower doses (0.5-2 mg/kg), F13714 distinctly and dose-dependently lowers rectal body temperature over a 2-hour period[1]. Moreover, at a dose of 2.5 mg/kg, it exhibits antidepressant and anxiolytic-like effects in naive rats[1].
Alias	F13714 fumarate

Chemical Properties

Molecular Weight	538.98
Formula	C25H29ClF2N4O5
Cas No.	208109-39-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 250 mg/mL (463.85 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8554 mL	9.2768 mL	18.5536 mL	92.7678 mL
5 mM	0.3711 mL	1.8554 mL	3.7107 mL	18.5536 mL
10 mM	0.1855 mL	0.9277 mL	1.8554 mL	9.2768 mL
20 mM	0.0928 mL	0.4638 mL	0.9277 mL	4.6384 mL
50 mM	0.0371 mL	0.1855 mL	0.3711 mL	1.8554 mL
100 mM	0.0186 mL	0.0928 mL	0.1855 mL	0.9277 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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