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Fluoxetine hydrochloride

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Purity:99.66%

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COA HPLC HNMR

Fluoxetine hydrochloride

Catalog No. T0450LCas No. 56296-78-7

Fluoxetine hydrochloride (Lilly110140) is the first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.

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Pack Size	Price	Availability
25 mg	$48	In Stock
50 mg	$64	In Stock
100 mg	$82	In Stock
200 mg	$148	In Stock
500 mg	$252	In Stock
1 mL x 10 mM (in DMSO)	$63	In Stock

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Product Introduction

Bioactivity

Description	Fluoxetine hydrochloride (Lilly110140) is the first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.
In vitro	When co-administered in adult male SD rats, fluoxetine and olanzapine induce a robust and sustained increase in extracellular dopamine levels, with concentrations surpassing baseline by 361% and 272%, respectively—significantly higher than when either drug is used alone. Additionally, fluoxetine reverses the prolonged latency of escape caused by unavoidable shocks in adult male SD rats.
In vivo	Fluoxetine accelerates the maturation of immature neurons. It enhances the proliferation of new cells in the dentate gyrus of the adult rat hippocampus, strengthens neurodependent long-term potentiation in the hippocampal dentate gyrus, and increases the number of proliferating cells in the prefrontal cortex.
Alias	Fluoxetine HCl, LY-110140, Lilly110140

Chemical Properties

Molecular Weight	345.787
Formula	C17H19ClF3NO
Cas No.	56296-78-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 3.5 mg/mL (10 mM)

DMSO: 50 mg/mL (144.6 mM)

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.8920 mL	14.4598 mL	28.9195 mL	144.5977 mL
5 mM	0.5784 mL	2.8920 mL	5.7839 mL	28.9195 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.2892 mL	1.4460 mL	2.8920 mL	14.4598 mL
20 mM	0.1446 mL	0.7230 mL	1.4460 mL	7.2299 mL
50 mM	0.0578 mL	0.2892 mL	0.5784 mL	2.8920 mL
100 mM	0.0289 mL	0.1446 mL	0.2892 mL	1.4460 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc