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Olanzapine (LY170053) is an atypical antipsychotic that is used currently in the treatment of schizophrenia and bipolar illness.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | 28 € | In Stock | |
50 mg | 37 € | In Stock | |
100 mg | 52 € | In Stock | |
200 mg | 76 € | In Stock | |
500 mg | 126 € | In Stock | |
1 mL x 10 mM (in DMSO) | 40 € | In Stock |
Description | Olanzapine (LY170053) is an atypical antipsychotic that is used currently in the treatment of schizophrenia and bipolar illness. |
In vitro | Olanzapine is a potent antagonist of DA and 5-HT receptors, which elevates the extracellular levels of DA metabolites, such as DOPAC, and the DA metabolite 3-methoxytyramine, in the prefrontal cortex, nucleus accumbens, and striatum of rats. Subcutaneous injections of Olanzapine (0.5-10 mg/kg) increase the levels of dopamine (DA) and norepinephrine (NE) in these regions in a dose-dependent manner. Additionally, Olanzapine significantly inhibits insulin, leading to the onset of obesity. |
In vivo | Olanzapine interacts with several key receptors associated with schizophrenia, demonstrating nanomolar affinity for dopamine, serotonin, alpha-1 adrenergic, and cholinergic receptors. Specifically, Olanzapine selectively targets striatal dopamine in the limbic and cortical regions of the brain, exhibiting no selectivity towards dopamine receptor subtypes. |
Alias | LY170053 |
Molecular Weight | 312.43 |
Formula | C17H20N4S |
Cas No. | 132539-06-1 |
Smiles | CN1CCN(CC1)C1=NC2=C(NC3=C1C=C(C)S3)C=CC=C2 |
Relative Density. | 1.32 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | 1eq. HCl: 31.2 mg/mL (100 mM) DMSO: 31.2 mg/mL (100 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
1eq. HCl/DMSO
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