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Olanzapine

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Catalog No. T1567Cas No. 132539-06-1
Alias LY170053

Olanzapine (LY170053) is an atypical antipsychotic that is used currently in the treatment of schizophrenia and bipolar illness.

Olanzapine

Olanzapine

🥰Excellent
Purity: 100%
Catalog No. T1567Alias LY170053Cas No. 132539-06-1
Olanzapine (LY170053) is an atypical antipsychotic that is used currently in the treatment of schizophrenia and bipolar illness.
Pack SizePriceAvailabilityQuantity
25 mg28 €In Stock
50 mg37 €In Stock
100 mg52 €In Stock
200 mg76 €In Stock
500 mg126 €In Stock
1 mL x 10 mM (in DMSO)40 €In Stock
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Product Introduction

Bioactivity
Description
Olanzapine (LY170053) is an atypical antipsychotic that is used currently in the treatment of schizophrenia and bipolar illness.
In vitro
Olanzapine is a potent antagonist of DA and 5-HT receptors, which elevates the extracellular levels of DA metabolites, such as DOPAC, and the DA metabolite 3-methoxytyramine, in the prefrontal cortex, nucleus accumbens, and striatum of rats. Subcutaneous injections of Olanzapine (0.5-10 mg/kg) increase the levels of dopamine (DA) and norepinephrine (NE) in these regions in a dose-dependent manner. Additionally, Olanzapine significantly inhibits insulin, leading to the onset of obesity.
In vivo
Olanzapine interacts with several key receptors associated with schizophrenia, demonstrating nanomolar affinity for dopamine, serotonin, alpha-1 adrenergic, and cholinergic receptors. Specifically, Olanzapine selectively targets striatal dopamine in the limbic and cortical regions of the brain, exhibiting no selectivity towards dopamine receptor subtypes.
AliasLY170053
Chemical Properties
Molecular Weight312.43
FormulaC17H20N4S
Cas No.132539-06-1
SmilesCN1CCN(CC1)C1=NC2=C(NC3=C1C=C(C)S3)C=CC=C2
Relative Density.1.32 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
1eq. HCl: 31.2 mg/mL (100 mM)
DMSO: 31.2 mg/mL (100 mM)
Solution Preparation Table
1eq. HCl/DMSO
1mg5mg10mg50mg
1 mM3.2007 mL16.0036 mL32.0072 mL160.0358 mL
5 mM0.6401 mL3.2007 mL6.4014 mL32.0072 mL
10 mM0.3201 mL1.6004 mL3.2007 mL16.0036 mL
20 mM0.1600 mL0.8002 mL1.6004 mL8.0018 mL
50 mM0.0640 mL0.3201 mL0.6401 mL3.2007 mL
100 mM0.0320 mL0.1600 mL0.3201 mL1.6004 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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