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Olanzapine
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Olanzapine
Catalog No. T1567Cas No. 132539-06-1
Olanzapine (LY170053) is an atypical antipsychotic that is used currently in the treatment of schizophrenia and bipolar illness.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $30 | In Stock | |
| 50 mg | $39 | In Stock | |
| 100 mg | $55 | In Stock | |
| 200 mg | $80 | In Stock | |
| 500 mg | $133 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $43 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Olanzapine (LY170053) is an atypical antipsychotic that is used currently in the treatment of schizophrenia and bipolar illness. |
| In vitro | Olanzapine is a potent antagonist of DA and 5-HT receptors, which elevates the extracellular levels of DA metabolites, such as DOPAC, and the DA metabolite 3-methoxytyramine, in the prefrontal cortex, nucleus accumbens, and striatum of rats. Subcutaneous injections of Olanzapine (0.5-10 mg/kg) increase the levels of dopamine (DA) and norepinephrine (NE) in these regions in a dose-dependent manner. Additionally, Olanzapine significantly inhibits insulin, leading to the onset of obesity. |
| In vivo | Olanzapine interacts with several key receptors associated with schizophrenia, demonstrating nanomolar affinity for dopamine, serotonin, alpha-1 adrenergic, and cholinergic receptors. Specifically, Olanzapine selectively targets striatal dopamine in the limbic and cortical regions of the brain, exhibiting no selectivity towards dopamine receptor subtypes. |
| Alias | LY170053 |
| Molecular Weight | 312.43 |
| Formula | C17H20N4S |
| Cas No. | 132539-06-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
| Solubility Information | 1eq. HCl: 31.2 mg/mL (100 mM) DMSO: 31.2 mg/mL (100 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
1eq. HCl
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Keywords
InhibitorBeta ReceptorcellOlanzapineApoptosisMuscarinic acetylcholine receptormAChRDopamine ReceptorAdrenergic ReceptordamageMitophagyinhibitantipsychoticSerotonin Receptorneuronal5-HT Receptoranticholinergic5-hydroxytryptamine ReceptorAutophagyLY-170053Mitochondrial Autophagy5-HT2mitochondrialSH-SY5YLY 170053
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