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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $39 | In Stock | |
10 mg | $64 | In Stock | |
25 mg | $129 | In Stock | |
50 mg | $188 | In Stock | |
100 mg | $283 | In Stock | |
500 mg | $688 | In Stock | |
1 mL x 10 mM (in DMSO) | $46 | In Stock |
Description | Phillyrin (Forsythin) is a novel AMPK activator, has anti-obesity effects in nutritive obesity mice, it can prevent lipid accumulation in HepG2 cells by blocking the expression of SREBP-1c and FAS through LKB1/AMPK activation. Phillyrin(Forsythin) may be a new preventive agent of acute lung injury in the clinical setting, it potentially contributes to the suppression of the activation of MAPK and NF-κB pathways, it also has protective effects on H2O2-induced oxidative stress and apoptosis in PC12 cells. |
In vitro | Phillyrin suppressed high glucose-induced lipid accumulation in HepG2 cells. Phillyrin strongly inhibited high glucose-induced fatty acid synthase (FAS) expression by modulating sterol regulatory element-binding protein-1c (SREBP-1c) activation. Moreover, use of the pharmacological AMP-activated protein kinase (AMPK) inhibitor revealed that AMPK is essential for suppressing SREBP-1c expression in Phillyrin-treated cells. Liver kinase B1 (LKB1) phosphorylation is required for the Phillyrin-enhanced activation of AMPK in HepG2 hepatocytes. |
In vivo | Phillyrin has anti-obesity effect in nutritive obesity mice. Phillyrin could lower wet weight of fat (P < 0.01), fat index (P < 0.05 or P < 0.01), the diameter of fat cell and Lee's index (P < 0.05), decrease the jejunum microvillus area, lower the level of serum triglyceride and cholesterol. |
Alias | Forsythin |
Molecular Weight | 534.55 |
Formula | C27H34O11 |
Cas No. | 487-41-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 91 mg/mL(170.2 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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