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ABTL-0812 induces endoplasmic reticulum (ER) stress-mediated autophagy, and with anti-cancer activity.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,200 | 6-8 weeks | |
50 mg | $1,570 | 6-8 weeks | |
100 mg | $2,500 | 6-8 weeks |
Description | ABTL-0812 induces endoplasmic reticulum (ER) stress-mediated autophagy, and with anti-cancer activity. |
In vitro | cell viability of squamous NSCLC H157 cells inhibited by ABTL-0812 (ABTL0812; 10-100 μM; 48 hours). Compared with squamous NSCLC H157 cells, human lung fibroblast cell line MRC-5 are resistant to ABTL0812 treatment. |
In vivo | In human lung and pancreatic xenografts, ABTL-0812 (ABTL0812; 120 mg/kg; oral gavage; 5 times per week; for 33 d) induces ER stress. In vivo, ABTL-0812 induces hallmarks of ER stress . ABTL-0812 increases ATF4 and HSPA5 expression in mice bearing MiaPaca2 and A549 xenograft, respectively. |
Alias | α-Hydroxylinoleic acid |
Molecular Weight | 296.44 |
Formula | C18H32O3 |
Cas No. | 57818-44-7 |
Relative Density. | 0.970 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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