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[6]-Gingerol

🥰Excellent
Catalog No. T3405Cas No. 23513-14-6
Alias gingerol, 6-Gingerol, (S)-(+)-[6]Gingerol

[6]-Gingerol ((S)-(+)-[6]Gingerol), an antioxidant, protects HL-60 cells from oxidative stress. It has protective effects for Yous tumors in the pancreas, ovaries, breast tissue, the bowel, among other tissues.

[6]-Gingerol

[6]-Gingerol

🥰Excellent
Purity: 99.59%
Catalog No. T3405Alias gingerol, 6-Gingerol, (S)-(+)-[6]GingerolCas No. 23513-14-6
[6]-Gingerol ((S)-(+)-[6]Gingerol), an antioxidant, protects HL-60 cells from oxidative stress. It has protective effects for Yous tumors in the pancreas, ovaries, breast tissue, the bowel, among other tissues.
Pack SizePriceAvailabilityQuantity
5 mg$35In Stock
10 mg$50In Stock
25 mg$81In Stock
50 mg$119In Stock
100 mg$175In Stock
200 mg$258In Stock
1 mL x 10 mM (in DMSO)$34In Stock
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Purity:99.59%
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Product Introduction

Bioactivity
Description
[6]-Gingerol ((S)-(+)-[6]Gingerol), an antioxidant, protects HL-60 cells from oxidative stress. It has protective effects for Yous tumors in the pancreas, ovaries, breast tissue, the bowel, among other tissues.
In vitro
[6]-Gingerol selectively inhibits proliferation and induces apoptosis in colon cancer cells while sparing normal colon cells. It modulates cell signaling by down-regulating phorbol myristate acetate-induced phosphorylation of ERK1/2 and JNK MAP kinases and reducing AP-1 transcription factor activation, with minimal impact on p38 MAP kinase phosphorylation and NF-kappa B activation[1]. Moreover, [6]-gingerol enhances intestinal barrier function and diminishes proinflammatory responses in DSS-treated Caco-2 monolayers, partly by activating AMPK[2]. Additionally, it significantly reduces osteosarcoma cell viability in a dose-dependent manner, increases sub-G1 cell cycle arrest, and activates caspase cascades while adjusting Bcl2 and Bax protein levels[3].
In vivo
In animal studies, [6]-gingerol effectively mitigates DSS-induced colitis symptoms by reversing body weight loss, decreasing intestinal bleeding, and preventing colon shortening. It also inhibits the DSS-induced increase in proinflammatory cytokines (IL-1β, TNFα, and IL-12)[2].
Cell Research
[6]-gingerol stock (20 mg/mL) is prepared in ethanol and the working concentrations are prepared by diluting this stock in dimethyl sufoxide (DMSO). For MTT assay, 5×103 cells/well of human colon cancer cells and 104 cells/well of mouse IECs are seeded in 96-well plates. Cells are treated with [6]-gingerol for 48 h,72 h or 96 h before performing MTT assay and for 16 h before Annexin-V staining[1].
Aliasgingerol, 6-Gingerol, (S)-(+)-[6]Gingerol
Chemical Properties
Molecular Weight294.39
FormulaC17H26O4
Cas No.23513-14-6
SmilesCCCCC[C@H](O)CC(=O)CCc1ccc(O)c(OC)c1
Relative Density.1.083 g/cm3
Storage & Solubility Information
Storagestore at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble
DMSO: 50 mg/mL (169.84 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.3969 mL16.9843 mL33.9685 mL169.8427 mL
5 mM0.6794 mL3.3969 mL6.7937 mL33.9685 mL
10 mM0.3397 mL1.6984 mL3.3969 mL16.9843 mL
20 mM0.1698 mL0.8492 mL1.6984 mL8.4921 mL
50 mM0.0679 mL0.3397 mL0.6794 mL3.3969 mL
100 mM0.0340 mL0.1698 mL0.3397 mL1.6984 mL

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