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Dihydrocurcumin
🥰Excellent
Catalog No. T3S1701Cas No. 76474-56-1
Dihydrocurcumin is the main metabolite of curcumin, which can reduce fat accumulation and oxidative stress response. Dihydrocurcumin can regulate the mRNA and protein expression levels of SREBP-1C, PNPLA3 and PPARα, increase the protein expression levels of pAKT and PI3K, and reduce the intracellular NO and ROS contents through Nrf2 signaling pathway.
Dihydrocurcumin
🥰Excellent
Purity: 97.23%
Catalog No. T3S1701Cas No. 76474-56-1
Dihydrocurcumin is the main metabolite of curcumin, which can reduce fat accumulation and oxidative stress response. Dihydrocurcumin can regulate the mRNA and protein expression levels of SREBP-1C, PNPLA3 and PPARα, increase the protein expression levels of pAKT and PI3K, and reduce the intracellular NO and ROS contents through Nrf2 signaling pathway.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $128 | In Stock | |
| 5 mg | $228 | In Stock | |
| 10 mg | $378 | In Stock | |
| 25 mg | $671 | In Stock |
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Purity:97.23%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Dihydrocurcumin is the main metabolite of curcumin, which can reduce fat accumulation and oxidative stress response. Dihydrocurcumin can regulate the mRNA and protein expression levels of SREBP-1C, PNPLA3 and PPARα, increase the protein expression levels of pAKT and PI3K, and reduce the intracellular NO and ROS contents through Nrf2 signaling pathway. |
| In vitro | Colon bacteria may mediate the transformation of curcumin, but this metabolism has not been well studied. Methods AND RESULTS: The metabolism of curcumin to Escherichia Ferguson (ATCC 35469) and two strains of Escherichia coli (ATCC 8739 and DH10B) was studied in modified colonic bacteria (mMCB) medium of porcine cecal fluid with or without medication. LC-MS analysis showed that after fermentation for 36 h, the conversion rate of curcumin was 16-37%, the conversion rate of demethoxycurcumin (DMC) was 6-16%, the conversion rate of dimethoxycurcumin (bi-DMC) was 7-15%, and the conversion rate of dimethoxycurcumin (bi-DMC) was 7-15%. The amount of curcumin degradation varies with different strains and medium. Three metabolites (dihydrocurcumin (DHC), tetrahydrocurcumin (THC) and ferulic acid (FA)) were identified in the fermentation culture of all strains. In addition, a compound of m/z [M-H](-) 470 was found and identified as curcumin-adduct (curcumin-L-cysteine) by precise mass FT-ICR-MS. Conclusion: This study provides a new scheme for the bacterial metabolism of curcumin[1]. |
| Molecular Weight | 370.4 |
| Formula | C21H22O6 |
| Cas No. | 76474-56-1 |
| Smiles | COc1cc(CCC(=O)\C=C(/O)\C=C\c2ccc(O)c(OC)c2)ccc1O |
| Relative Density. | 1.277g/cm3 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 22.5 mg/mL (60.7 mM), Sonication and heating to 60℃ are recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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