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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,520 | 6-8 weeks | |
50 mg | $1,980 | 6-8 weeks | |
100 mg | $2,500 | 6-8 weeks |
Description | BN201, a chemical compound, actively crosses the blood-brain barrier and activates the IGF-1 pathway, which is associated with stress response and neuron survival. It facilitates neuronal differentiation and the maturation of precursor cells into oligodendrocytes with an EC50 of 6.3 μM, in addition to promoting the myelination of new axons with an EC50 of 16.6 μM in vitro. BN201 exhibits potent neuroprotective effects[1]. |
In vitro | BN201 promotes the survival of cultured neural cells when subjected to oxidative stress or when deprived of trophic factors[1]. BN201 (10 μM; 0.5-4 hours; Hela cells) treatment induces the phosphorylation of NDGR1 in Hela cells in a time-dependent manner[1]. |
In vivo | 'Daily intraperitoneal injection of BN201 (12.5-150 mg/kg) for 30 days in female C57BL/6 mice results in reduced axonal and neuronal loss in the spinal cord and optic nerve compared to placebo-treated animals[1].' |
Molecular Weight | 491.6 |
Formula | C25H38FN5O4 |
Cas No. | 1361200-34-1 |
Storage |
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