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BN201 (OCS-05) is a drug with neuroprotective and myelin repair effects, which acts mainly by activating serum glucocorticoid kinase-2 (SGK2), which in turn activates the FOXO3 pathway to promote neuronal survival and myelin repair. It is mainly used for the treatment of inflammatory neurological diseases such as multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE).BN201 is able to regulate multiple kinases in the insulin growth factor 1 (IGF1) pathway and cross the blood-brain barrier.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $293 | In Stock | |
5 mg | $722 | In Stock | |
10 mg | $987 | In Stock | |
25 mg | $1,520 | In Stock | |
50 mg | $1,980 | In Stock | |
100 mg | $2,500 | In Stock |
Description | BN201 (OCS-05) is a drug with neuroprotective and myelin repair effects, which acts mainly by activating serum glucocorticoid kinase-2 (SGK2), which in turn activates the FOXO3 pathway to promote neuronal survival and myelin repair. It is mainly used for the treatment of inflammatory neurological diseases such as multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE).BN201 is able to regulate multiple kinases in the insulin growth factor 1 (IGF1) pathway and cross the blood-brain barrier. |
In vitro | BN201 promotes the survival of cultured neural cells when subjected to oxidative stress or when deprived of trophic factors[1]. BN201 (10 μM; 0.5-4 hours; Hela cells) treatment induces the phosphorylation of NDGR1 in Hela cells in a time-dependent manner[1]. |
In vivo | 'Daily intraperitoneal injection of BN201 (12.5-150 mg/kg) for 30 days in female C57BL/6 mice results in reduced axonal and neuronal loss in the spinal cord and optic nerve compared to placebo-treated animals[1].' |
Molecular Weight | 491.6 |
Formula | C25H38FN5O4 |
Cas No. | 1361200-34-1 |
Smiles | O=C(N)CN(C(=O)CN(C(=O)CNCCC=1C=CC=CC1F)CC(C)C)CCCN2C(=O)CCC2 |
Relative Density. | 1.192 g/cm3 (Predicted) |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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