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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $41 | In Stock | |
2 mg | $57 | In Stock | |
5 mg | $116 | In Stock | |
10 mg | $196 | In Stock | |
25 mg | $348 | In Stock | |
50 mg | $505 | In Stock | |
1 mL x 10 mM (in DMSO) | $129 | In Stock |
Description | AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II. |
Targets&IC50 | Akt1:38 nM, p70 S6K:8 nM, ROCK2:4 nM, PKA:3 nM, ROCK1:6 nM |
Kinase Assay | In vitro kinase assays: AT13148 is assayed against 40 kinases and the percentage inhibition at 10 μM of AT13148 is determined. Individual IC50 values are measured for selected kinases using ATP concentrations equivalent to the Km for each enzyme. |
Cell Research | Cytotoxicity is determined using a 72 h Alamar Blue assay or a 96 h SRB assay. (Only for Reference) |
Molecular Weight | 313.78 |
Formula | C17H16ClN3O |
Cas No. | 1056901-62-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | H2O: < 1 mg/mL (insoluble or slightly soluble) Ethanol: < 1 mg/mL (insoluble or slightly soluble) DMSO: 58 mg/mL (184.8 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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