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B355252

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Purity:99.92%

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COA HNMR HPLC

B355252

Catalog No. T8869Cas No. 1261576-81-1

B355252 protects against cell death caused by glutamate-evoked oxidative stress. B355252 shows neuroprotective effect, potentiating nerve growth factor (NGF)-induced neurite outgrowth.

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Pack Size	Price	Availability
1 mg	$118	In Stock
5 mg	$332	In Stock
10 mg	$582	In Stock
25 mg	$933	Backorder
50 mg	$1,270	Backorder
1 mL x 10 mM (in DMSO)	$429	In Stock

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Product Introduction

Bioactivity

Description

B355252 protects against cell death caused by glutamate-evoked oxidative stress. B355252 shows neuroprotective effect, potentiating nerve growth factor (NGF)-induced neurite outgrowth.

In vitro

Method: HT22 cells were pretreated for 2 hours with various concentrations of B355252 (0.625-20 μM). This was followed by the addition of 300 μM CoCl2 and incubation at 37oC for 24 hours. At the end of this time, cell viability was determined by resazurin assay as described below. Result: From 0.625 to 5 μM, B355252 increased cell viability in a dose-dependent manner, protecting against CoCl2-induced hypoxia. Above 5 μM, B355252 became toxic to the cells and, synergistically with CoCl2, decreased cell viability.

Chemical Properties

Molecular Weight	514.06
Formula	C25H24ClN3O3S2
Cas No.	1261576-81-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 25 mg/mL (48.63 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9453 mL	9.7265 mL	19.4530 mL	97.2649 mL
5 mM	0.3891 mL	1.9453 mL	3.8906 mL	19.4530 mL
10 mM	0.1945 mL	0.9726 mL	1.9453 mL	9.7265 mL
20 mM	0.0973 mL	0.4863 mL	0.9726 mL	4.8632 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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Tech Support

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Keywords

neurite outgrowthischemic neuronsHT22glutamateInhibitorApoptosisDNA damageinhibitNGFLDH levelROS productionB 355252Parkinson diseasephenoxy thiophene sulfonamideB-355252B355252