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Vasonatrin Peptide (VNP) TFA

Name: Vasonatrin Peptide (VNP) TFA
Brand: TargetMol
SKU: T78007
Price: 39 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T78007

Vasonatrin Peptide (VNP) TFA, a chimeric compound derived from atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP), exhibits venodilating properties reminiscent of CNP, natriuretic effects akin to ANP, as well as unique arterial vasodilating capabilities not characteristic of either parent peptide. Additionally, VNP TFA confers cardioprotection in diabetic ischemia-reperfusion injury by attenuating endoplasmic reticulum (ER) stress through the cGMP-PKG signaling cascade [1] [2] [3].

Vasonatrin Peptide (VNP) TFA

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Catalog No. T78007

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Product Introduction

Bioactivity

Description	Vasonatrin Peptide (VNP) TFA, a chimeric compound derived from atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP), exhibits venodilating properties reminiscent of CNP, natriuretic effects akin to ANP, as well as unique arterial vasodilating capabilities not characteristic of either parent peptide. Additionally, VNP TFA confers cardioprotection in diabetic ischemia-reperfusion injury by attenuating endoplasmic reticulum (ER) stress through the cGMP-PKG signaling cascade [1] [2] [3].
In vitro	Vasonatrin Peptide (VNP) significantly augments both mRNA expression and protein secretion of adiponectin while concurrently inhibiting IL-6 production in mature adipocytes. Additionally, VNP notably elevates intracellular cGMP concentrations. These VNP effects can be replicated by 8-br-cGMP, but are inhibited by either HS-142-1, or KT-5823 [2].
In vivo	Vasonatrin peptide, administered intravenously at a dose of 100 μg/kg 10 minutes before reperfusion, mitigates myocardial ischemia-reperfusion injury in diabetic rats [3].

Chemical Properties

Molecular Weight	2979.39
Formula	C₁₂₆H₁₉₉N₃₆O₃₈S₃F₃

Storage & Solubility Information

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keep away from moisture | Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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