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Gamma-glutamylcysteine TFA (γ-glutamylcysteine TFA) is a precursor of glutathione (GSH) with antioxidant and anti-inflammatory properties. It alleviates oxidative stress and mitochondrial damage induced by ethanol in hepatocytes by increasing cellular GSH, SOD activity, and mitochondrial membrane potential, protecting cells from alcohol-induced liver disease (ALD) by inhibiting oxidative stress, reducing inflammation, and preventing cell apoptosis.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | 28 € | In Stock | |
10 mg | 43 € | In Stock | |
25 mg | 80 € | In Stock | |
50 mg | 134 € | In Stock | |
100 mg | 197 € | In Stock | |
200 mg | 282 € | In Stock | |
1 mL x 10 mM (in DMSO) | 29 € | In Stock |
Description | Gamma-glutamylcysteine TFA (γ-glutamylcysteine TFA) is a precursor of glutathione (GSH) with antioxidant and anti-inflammatory properties. It alleviates oxidative stress and mitochondrial damage induced by ethanol in hepatocytes by increasing cellular GSH, SOD activity, and mitochondrial membrane potential, protecting cells from alcohol-induced liver disease (ALD) by inhibiting oxidative stress, reducing inflammation, and preventing cell apoptosis. |
In vitro | Gamma-glutamylcysteine TFA (20, 40, and 80 μM) pretreated L02 cells for 2 hours and exposed to ethanol for 24 hours. The results showed that γ-GC alleviated the oxidative stress and mitochondrial damage induced by alcohol by increasing the activity of GSH, SOD and mitochondrial membrane potential. [1] Gamma-glutamylcysteine TFA (0-160 μM,48h) alleviates TNBS-induced IBD by modulating macrophage polarization. [2] |
In vivo | Gamma-glutamylcysteine TFA (600 mg/kg or 1200 mg/kg oral tube feeding) improved IBD survival and colon injury. [2] |
Alias | γ-glutamylcysteine TFA |
Molecular Weight | 364.3 |
Formula | C10H15F3N2O7S |
Cas No. | 283159-88-6 |
Smiles | C(C(O)=O)(F)(F)F.[C@@H](NC(CC[C@@H](C(O)=O)N)=O)(C(O)=O)CS |
Relative Density. | no data available |
Storage | store under nitrogen,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 80.00 mg/mL (219.60 mM), Sonication is recommended. H2O: 80.00 mg/mL (219.60 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO/H2O
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