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Astressin acetate
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Catalog No. TP1448L
Alias Astressin acetate (170809-51-5 Free base)
Astressin acetate is an antagonist of corticotropin releasing factor (CRF) with low affinity for the CRF binding protein and high affinity for the cloned pituitary receptor(Ki = 2 nM).
Astressin acetate
🥰Excellent
Purity: 96.87%
Catalog No. TP1448LAlias Astressin acetate (170809-51-5 Free base)
Astressin acetate is an antagonist of corticotropin releasing factor (CRF) with low affinity for the CRF binding protein and high affinity for the cloned pituitary receptor(Ki = 2 nM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $236 | In Stock | |
| 5 mg | $942 | In Stock | |
| 10 mg | $1,410 | In Stock | |
| 25 mg | $2,540 | In Stock |
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Urocortin (rat) acetate
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Purity:96.87%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Astressin acetate is an antagonist of corticotropin releasing factor (CRF) with low affinity for the CRF binding protein and high affinity for the cloned pituitary receptor(Ki = 2 nM). |
| In vitro | Astressin acetate exhibits high affinity for cloned human CRF-RA1 stably expressed in CHO cells and high potency to inhibit ACTH secretion[2]. |
| In vivo | Astressin acetate (i.c.v. 30 min before and 10 min after seizures) decreases damage in some hippocampal cell fields by as much as 84%. Astressin acetate protects even if administered only 10 min following excitotoxin exposure[1]. Astressin acetate is significantly more potent than any previously tested antagonist in reducing hypophyseal corticotropin secretion in stressed or adrenalectomized rats. Astressin acetate (30 and 100 μg/kg; i.v.) produces a significant decrease in ACTH levels at 45 and 90 min, respectively[2]. Astressin acetate significantly reverses the anxiogenic-like response induced by both social stress and i.c.v. rat/humanCRF (r/hCRF) on the elevated plus-maze, but fails to block the effects of r/hCRF-induced locomotor activity in a familiar environment[3]. |
| Alias | Astressin acetate (170809-51-5 Free base) |
| Molecular Weight | 3623.21 |
| Formula | C163H273N49O44 |
| Smiles | CC(O)=O.O=C(O)CC[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](N)CC1=CC=CC=C1)=O)CC2=CNC=N2)=O)CC(C)C)=O)CC(C)C)=O)CCCNC(N)=N)=O)CCC(O)=O)=O)C(C)C)=O)CC(C)C)=O)CCC(O)=O)=O)CCCC)=O)C)=O)CCCNC(N)=N)=O)C)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC3)C(N[C@@H](C)C(N[C@@H](CC4=CNC=N4)C(N[C@H](C(N[C@@H](CC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CCCC)C(N[C@@H](CCC(O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@@H](C)CC)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)CCCCNC3=O)=O)=O)=O)=O)=O)=O)=O)=O |
Storage & Solubility Information
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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