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CP 376395

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Purity:99.96%

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COA HPLC HNMR

CP 376395

Catalog No. T4329Cas No. 175140-00-8

CP 376395 (CP-316311) is an effective and specific Corticotropin-releasing factor 1 (CRF1) receptor antagonist.

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Pack Size	Price	Availability
1 mg	$35	In Stock
5 mg	$86	In Stock
10 mg	$138	In Stock
25 mg	$282	In Stock
50 mg	$448	In Stock
100 mg	$712	In Stock
1 mL x 10 mM (in DMSO)	$94	In Stock

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Product Introduction

Bioactivity

Description	CP 376395 (CP-316311) is an effective and specific Corticotropin-releasing factor 1 (CRF1) receptor antagonist.
In vitro	It is highly selective for the human CRF1 receptor subtype,and exhibits affinities against 40 neurotransmitter receptor and ion channels(>1 μM).
In vivo	Pretreatment with CP 376395 (ID50=17.8 mg/kg, p.o.) reverses the excitation of locus coeruleus neurons induced by icv CRF (3 μg) completely blocked the enhanced startle response, while pretreatment with CP 376395(10 mg/kg, p.o.) induced by icv CRF (1 μg) is partially blocked.
Kinase Assay	In supernatants from cells, which are incubated in OSS_128167 (100 μM) for 18 hours,TNF-a levels are measured .
Animal Research	Beagle dogs weighing between 8 and 15 kg are administered with CP 376395 hydrochloride salt (1.0 mg/kg) into the cephalic vein of the foreleg. Beagle dogs are treated with CP 376395(10 mg/mL) prepared in 0.1% methyl cellulose at pH 2 by oral.
Alias	CP-316311

Chemical Properties

Molecular Weight	326.48
Formula	C21H30N2O
Cas No.	175140-00-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 0.1 mg/mL (insoluble)

DMSO: 100 mg/mL (306.30 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0630 mL	15.3149 mL	30.6297 mL	153.1487 mL
5 mM	0.6126 mL	3.0630 mL	6.1259 mL	30.6297 mL
10 mM	0.3063 mL	1.5315 mL	3.0630 mL	15.3149 mL
20 mM	0.1531 mL	0.7657 mL	1.5315 mL	7.6574 mL
50 mM	0.0613 mL	0.3063 mL	0.6126 mL	3.0630 mL
100 mM	0.0306 mL	0.1531 mL	0.3063 mL	1.5315 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc