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Verucerfont
🥰Excellent
Catalog No. T7361Cas No. 885220-61-1
Alias NBI77860, GSK561679
Verucerfont (NBI77860) is an antagonist of corticotropin-releasing factor receptor 1 (CRF1) .
Verucerfont
🥰Excellent
Purity: 99.95%
Catalog No. T7361Alias NBI77860, GSK561679Cas No. 885220-61-1
Verucerfont (NBI77860) is an antagonist of corticotropin-releasing factor receptor 1 (CRF1) .
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $58 | In Stock | |
| 2 mg | $84 | In Stock | |
| 5 mg | $139 | In Stock | |
| 10 mg | $228 | In Stock | |
| 25 mg | $418 | In Stock | |
| 50 mg | $637 | In Stock | |
| 100 mg | $893 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $153 | In Stock |
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Purity:99.95%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Verucerfont (NBI77860) is an antagonist of corticotropin-releasing factor receptor 1 (CRF1) . |
| Targets&IC50 | CRF BP:>1000 nM, CRF2:1000 nM, CRF1:~6.1nM |
| In vivo | Verucerfont potently blocked the HPA axis response to the dexamethasone-CRF test, but left alcohol craving unaffected.?Right amygdala responses to negative affective stimuli were significantly attenuated by verucerfont, but responses to alcohol-associated stimuli were increased in some brain regions, including left insula[1]. |
| Alias | NBI77860, GSK561679 |
| Molecular Weight | 406.48 |
| Formula | C22H26N6O2 |
| Cas No. | 885220-61-1 |
| Smiles | CC[C@H](Nc1cc(C)nc2c(c(C)nn12)-c1ccc(OC)cc1C)c1nc(C)no1 |
| Relative Density. | 1.29 g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 86.7 mg/mL (213.29 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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