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BiP inducer X

Catalog No. T30480Cas No. 101714-41-4
Alias BIX

BiP inducer X (BIX) is a selective inducer of immunoglobulin heavy chain binding protein (BiP)/GRP78 and an ER chaperone inducer. BiP inducer X prevents cell death in neurons and retinal cell lines.

BiP inducer X

BiP inducer X

Purity: 90%
Catalog No. T30480Alias BIXCas No. 101714-41-4
BiP inducer X (BIX) is a selective inducer of immunoglobulin heavy chain binding protein (BiP)/GRP78 and an ER chaperone inducer. BiP inducer X prevents cell death in neurons and retinal cell lines.
Pack SizePriceAvailabilityQuantity
5 mg$39In Stock
10 mg$64In Stock
25 mg$128In Stock
50 mg$222In Stock
100 mg$372In Stock
200 mg$549In Stock
1 mL x 10 mM (in DMSO)$43In Stock
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Purity:90%
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Product Introduction

Bioactivity
Description
BiP inducer X (BIX) is a selective inducer of immunoglobulin heavy chain binding protein (BiP)/GRP78 and an ER chaperone inducer. BiP inducer X prevents cell death in neurons and retinal cell lines.
In vitro
Pretreatment of BiP inducer X (5 μM; 12 hours) inhibits cell death induced by ER stress involving inhibited activation of caspases 3/7 and 4. In SK-N-SH cells, BiP inducer X (5 μM; 0-12 hours) increases BiP protein and is mediated by activation of ER stress response elements (ERSEs) through the ATF6 pathway[1].
In vivo
In male adult ddY mice, BiP inducer X (20 μg) reduces ER stress-induced apoptosis induced in the penumbra by MCA occlusion. BiP inducer X reduces the insults due to cerebral infarction[1].
AliasBIX
Chemical Properties
Molecular Weight209.22
FormulaC9H7NO3S
Cas No.101714-41-4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 45 mg/mL (215.08 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.7797 mL23.8983 mL47.7966 mL238.9829 mL
5 mM0.9559 mL4.7797 mL9.5593 mL47.7966 mL
10 mM0.4780 mL2.3898 mL4.7797 mL23.8983 mL
20 mM0.2390 mL1.1949 mL2.3898 mL11.9491 mL
50 mM0.0956 mL0.4780 mL0.9559 mL4.7797 mL
100 mM0.0478 mL0.2390 mL0.4780 mL2.3898 mL

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