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BiP inducer X

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BiP inducer X

Catalog No. T30480Cas No. 101714-41-4

BiP inducer X (BIX) is a selective inducer of immunoglobulin heavy chain binding protein (BiP)/GRP78 and an ER chaperone inducer. BiP inducer X prevents cell death in neurons and retinal cell lines.

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Pack Size	Price	Availability
5 mg	$39	In Stock
10 mg	$64	In Stock
25 mg	$128	In Stock
50 mg	$222	In Stock
100 mg	$372	In Stock
200 mg	$549	In Stock
1 mL x 10 mM (in DMSO)	$43	In Stock

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Product Introduction

Bioactivity

Description	BiP inducer X (BIX) is a selective inducer of immunoglobulin heavy chain binding protein (BiP)/GRP78 and an ER chaperone inducer. BiP inducer X prevents cell death in neurons and retinal cell lines.
In vitro	Pretreatment of BiP inducer X (5 μM; 12 hours) inhibits cell death induced by ER stress involving inhibited activation of caspases 3/7 and 4. In SK-N-SH cells, BiP inducer X (5 μM; 0-12 hours) increases BiP protein and is mediated by activation of ER stress response elements (ERSEs) through the ATF6 pathway[1].
In vivo	In male adult ddY mice, BiP inducer X (20 μg) reduces ER stress-induced apoptosis induced in the penumbra by MCA occlusion. BiP inducer X reduces the insults due to cerebral infarction[1].
Alias	BIX

Chemical Properties

Molecular Weight	209.22
Formula	C9H7NO3S
Cas No.	101714-41-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (215.08 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.7797 mL	23.8983 mL	47.7966 mL	238.9829 mL
5 mM	0.9559 mL	4.7797 mL	9.5593 mL	47.7966 mL
10 mM	0.4780 mL	2.3898 mL	4.7797 mL	23.8983 mL
20 mM	0.2390 mL	1.1949 mL	2.3898 mL	11.9491 mL
50 mM	0.0956 mL	0.4780 mL	0.9559 mL	4.7797 mL
100 mM	0.0478 mL	0.2390 mL	0.4780 mL	2.3898 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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