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ONO-2952

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Catalog No. T16393Cas No. 895169-20-7

ONO-2952 is more selective for TSPO than other receptors, transporters, ion channels, and enzymes. ONO-2952 is a potent and selective translocator protein 18 kDa (TSPO) antagonist (Ki: 0.33-9.30 nM for rat and human TSPO). ONO-2952 has the potential for irritable bowel syndrome treatment. ONO-2952 exerts its anti-stress effects through inhibition of excessive activation of the noradrenergic system in the brain without the amnesic effect.

ONO-2952

ONO-2952

😃Good
Catalog No. T16393Cas No. 895169-20-7
ONO-2952 is more selective for TSPO than other receptors, transporters, ion channels, and enzymes. ONO-2952 is a potent and selective translocator protein 18 kDa (TSPO) antagonist (Ki: 0.33-9.30 nM for rat and human TSPO). ONO-2952 has the potential for irritable bowel syndrome treatment. ONO-2952 exerts its anti-stress effects through inhibition of excessive activation of the noradrenergic system in the brain without the amnesic effect.
Pack SizePriceAvailabilityQuantity
25 mg$1,6706-8 weeks
50 mg$2,1806-8 weeks
100 mg$2,8006-8 weeks
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Product Introduction

Bioactivity
Description
ONO-2952 is more selective for TSPO than other receptors, transporters, ion channels, and enzymes. ONO-2952 is a potent and selective translocator protein 18 kDa (TSPO) antagonist (Ki: 0.33-9.30 nM for rat and human TSPO). ONO-2952 has the potential for i
Targets&IC50
TSPO (rat and human):(ki)0.33-9.30 nM
In vitro
ONO-2952 at a concentration of 10 μM displayed good selectivity for TSPO against 98 off-targets (<50% inhibition). ONO-2952 Ki value for the GABAA receptor is more than 600 times higher than that for TSPO. Determination of ONO-2952 Ki or IC50 values for the remaining 35 targets (50% inhibition at 10 μM) reveals Ki values of less than 1 μM only for 3 receptors, i.e. melatonin 2, progesterone B, and adrenergic α2C. The affinity of ONO-2952 for these receptors is at least 59 times lower than that for TSPO [1].
In vivo
ONO-2952 inhibits both neurosteroid accumulation and noradrenaline release in the brain of rats exposed to acute stress. ONO-2952 also inhibits conditioned fear stress-induced freezing behavior in rats. ONO-2952 (0.03-3 mg/kg; p.o.; male Sprague Dawley rats) treatment dose-dependently inhibits restraint stress-induced defecation in rats with brain TSPO occupancy of more than 50% [1].
Chemical Properties
Molecular Weight398.86
FormulaC22H20ClFN2O2
Cas No.895169-20-7
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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