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Beta-Zearalanol
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Catalog No. T14548Cas No. 42422-68-4
Beta-Zearalenol, a derivative of zearalenone (ZEA) capable of conjugating with glucuronic acid[2], is a mycotoxin produced by Fusarium spp. It induces apoptosis and oxidative stress in mammalian reproductive cells[1].
Beta-Zearalanol
🥰Excellent
Catalog No. T14548Cas No. 42422-68-4
Beta-Zearalenol, a derivative of zearalenone (ZEA) capable of conjugating with glucuronic acid[2], is a mycotoxin produced by Fusarium spp. It induces apoptosis and oxidative stress in mammalian reproductive cells[1].
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Product Introduction
Bioactivity
Chemical Properties
| Description | Beta-Zearalenol, a derivative of zearalenone (ZEA) capable of conjugating with glucuronic acid[2], is a mycotoxin produced by Fusarium spp. It induces apoptosis and oxidative stress in mammalian reproductive cells[1]. |
| In vitro | βeta-Zearalenol (0-200 μM; 24 hours) inhibits BGC proliferation dose-dependently, with an IC50 of 25 μM[1]. βeta-Zearalenol (0-10 μM; 72 hours) exhibits the highest inhibition of the cytokines IL-8, IL-1β, and TNF-α compared to ZEA or α-Zearalenol[2]. βeta-Zearalenol (0-100 μM; 72 hours) is highly toxic to HepG2 cells with an IC50 of 15.2 μM, showing synergistic effects when combined with ZEN or α-ZOL, resulting in IC50 values of 19.8 μM and 16.8 μM, respectively[2]. |
| Molecular Weight | 322.4 |
| Formula | C18H26O5 |
| Cas No. | 42422-68-4 |
| Relative Density. | 1.153g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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