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Bisabosqual A
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Catalog No. TN7642Cas No. 180027-46-7
Bisabosqual A is a potent asparagine synthetase (ASNS) inhibitor with an IC 50 of 10.7 μM, capable of covalently modifying the K556 site of the ASNS protein. It induces oxidative stress and apoptosis, while inhibiting autophagy, cell migration, and epithelial-mesenchymal transition (EMT), thereby slowing cancer cell development [1].
Bisabosqual A
😃Good
Catalog No. TN7642Cas No. 180027-46-7
Bisabosqual A is a potent asparagine synthetase (ASNS) inhibitor with an IC 50 of 10.7 μM, capable of covalently modifying the K556 site of the ASNS protein. It induces oxidative stress and apoptosis, while inhibiting autophagy, cell migration, and epithelial-mesenchymal transition (EMT), thereby slowing cancer cell development [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Bisabosqual A is a potent asparagine synthetase (ASNS) inhibitor with an IC 50 of 10.7 μM, capable of covalently modifying the K556 site of the ASNS protein. It induces oxidative stress and apoptosis, while inhibiting autophagy, cell migration, and epithelial-mesenchymal transition (EMT), thereby slowing cancer cell development [1]. |
| In vitro | Bisabosqual A inhibits the proliferation and migration of human non-small cell lung cancer A549 cells [1]. It induces a negative feedback pathway involving GCN2-eIF2α-ATF4, PI3K-AKT-mTORC1, and RAF-MEK-ERK axes. However, the combined effect of Bisabosqual A and rapamycin/torin-1 overcomes potential resistance triggered by the mTOR pathway [1]. |
| Molecular Weight | 384.47 |
| Formula | C23H28O5 |
| Cas No. | 180027-46-7 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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