FABPs ligand 6 (MF6) is a selective inhibitor of FABP5 and FABP7 that reduces levels of oxidative stress in the mouse spinal cord as well as lipopolysaccharide-stimulated interleukin-1β and tumor necrosis factor α accumulation in primary astrocyte cultures.FABPs ligand 6 has a potent protective function in oligodendrocytes of EAE mice through FABP5 inhibition. mitochondria with a strong protective function.

FABP5:874 nM (Kd), FABP7:20 nM (Kd)

FABP ligand 6 has exhibited a high binding affinity for FABP5 (KD=874 nM) and FABP7 (KD=20 nM), but not for FABP3 (KD=1038 nM). [1]
FABPs ligand 6 almost completely suppressed the upregulated oxidative stress levels and significantly decreased the number of 4-HNE-positive cells. [1]
FABPs ligand 6-treated astrocytes, significantly attenuated IL-1b and TNF-a levels, indicating a suppressed inflammatory response. [1]

EAE mice were orally administered FABPs ligand 6 (1 mg/kg), which is the maximum effective dose in brain ischemia 1 week before MOG immunisation of the EAE model. FABPs ligand 6 administration significantly reduced the severity of EAE. [1]