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BMS-309403

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Catalog No. T4534Cas No. 300657-03-8

BMS309403 is a potent and selective inhibitor of adipocyte fatty acid binding protein aFABP. It improves endothelial function in apolipoprotein E-deficient mice and cultured human endothelial cells. It interacts with the fatty acid binding pocket inside the protein and competitively inhibits the binding of endogenous fatty acids.

BMS-309403

BMS-309403

🥰Excellent
Purity: 99.54%
Catalog No. T4534Cas No. 300657-03-8
BMS309403 is a potent and selective inhibitor of adipocyte fatty acid binding protein aFABP. It improves endothelial function in apolipoprotein E-deficient mice and cultured human endothelial cells. It interacts with the fatty acid binding pocket inside the protein and competitively inhibits the binding of endogenous fatty acids.
Pack SizePriceAvailabilityQuantity
2 mg28 €In Stock
5 mg45 €In Stock
10 mg80 €In Stock
25 mg157 €In Stock
50 mg205 €In Stock
100 mg266 €In Stock
1 mL x 10 mM (in DMSO)50 €In Stock
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Purity:99.54%
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Product Introduction

Bioactivity
Description
BMS309403 is a potent and selective inhibitor of adipocyte fatty acid binding protein aFABP. It improves endothelial function in apolipoprotein E-deficient mice and cultured human endothelial cells. It interacts with the fatty acid binding pocket inside the protein and competitively inhibits the binding of endogenous fatty acids.
Targets&IC50
FABP3: 250 nM , FABP4:< 2 nM, FABP5: 350 nM
In vitro
Treatment with BMS309403 significantly reduced MCP-1 production in THP-1 macrophages in a dose- and time-dependent manner.[1]
In vivo
METHODS: 3 weeks after the onset of diabetes, mice were orally treated with BMS309403 (40 mg/kg, daily) for 3 weeks. During treatment, monitor blood sugar levels.
RESULTS BMS309403 can significantly reduce the protein expression of FABP4 in mouse retinal tissue and partially reduce blood glucose levels in mice. [2]
Chemical Properties
Molecular Weight474.55
FormulaC31H26N2O3
Cas No.300657-03-8
SmilesCCc1c(c(nn1-c1ccccc1-c1cccc(OCC(O)=O)c1)-c1ccccc1)-c1ccccc1
Relative Density.1.17 g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: 20 mM, Heating is recommended.
DMSO: 50 mg/mL (105.36 mM)
Solution Preparation Table
Ethanol/DMSO
1mg5mg10mg50mg
1 mM2.1073 mL10.5363 mL21.0726 mL105.3630 mL
5 mM0.4215 mL2.1073 mL4.2145 mL21.0726 mL
10 mM0.2107 mL1.0536 mL2.1073 mL10.5363 mL
20 mM0.1054 mL0.5268 mL1.0536 mL5.2681 mL
DMSO
1mg5mg10mg50mg
50 mM0.0421 mL0.2107 mL0.4215 mL2.1073 mL
100 mM0.0211 mL0.1054 mL0.2107 mL1.0536 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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