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Lipoxin A4
🥰Excellent
Catalog No. T36051Cas No. 89663-86-5
Alias LXA4
Lipoxin A4 (LXA4) is a lipoxygenase-derived arachidonate-like mediator with anti-inflammatory properties.Lipoxin A4 attenuates MSU crystal-induced NLRP3 inflammasome activation through inhibition of Nrf2, and regulates M1/M2 macrophage polarization through the FPR2-IRF pathway.Lipoxin inhibits oxidative stress and inflammation.
Lipoxin A4
🥰Excellent
Purity: 95%
Catalog No. T36051Alias LXA4Cas No. 89663-86-5
Lipoxin A4 (LXA4) is a lipoxygenase-derived arachidonate-like mediator with anti-inflammatory properties.Lipoxin A4 attenuates MSU crystal-induced NLRP3 inflammasome activation through inhibition of Nrf2, and regulates M1/M2 macrophage polarization through the FPR2-IRF pathway.Lipoxin inhibits oxidative stress and inflammation.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 μg (283.71 µM * 250 μL in Ethanol) | $899 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Lipoxin A4 (LXA4) is a lipoxygenase-derived arachidonate-like mediator with anti-inflammatory properties.Lipoxin A4 attenuates MSU crystal-induced NLRP3 inflammasome activation through inhibition of Nrf2, and regulates M1/M2 macrophage polarization through the FPR2-IRF pathway.Lipoxin inhibits oxidative stress and inflammation. |
| In vitro | Lipoxin A4 (LXA4; NHEKs) inhibits the expression of IL-6 and IL-8, downregulates the expression of cyclin D1, and suppresses the ERK1/2 phosphorylation and NF-kB-p65 nuclear translocation in NHEKs.[2] Lipoxin A4 (100 nM; preincubation for 30 minutes; NHEKs) inhibits the NHEKs proliferation with or without stimulating by LPS (10 μg/mL).[2] Lipoxin A4 (100 nM; preincubation for 30 minutes) downregulates the LPS-induced secretion and expression of HMGB1 in keratinocytes.[1] |
| Alias | LXA4 |
| Molecular Weight | 352.47 |
| Formula | C20H32O5 |
| Cas No. | 89663-86-5 |
| Smiles | [C@H]([C@H](CCCC(O)=O)O)(/C=C/C=C/C=C\C=C\[C@H](CCCCC)O)O |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | PBS (pH 7.2): 0.05 mg/mL H2O: < 1 mg/mL (insoluble or slightly soluble.) Ethanol: 30 mg/mL (85.11 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
Ethanol
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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