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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,970 | 8-10 weeks | |
50 mg | $2,580 | 8-10 weeks | |
100 mg | $3,400 | 8-10 weeks |
Description | SAR502250 is a potent, selective, ATP-competitive, orally active, and brain-penetrant GSK3 inhibitor with a human GSK-3β IC50 value of 12 nM, exhibiting antidepressant-like activity and being researched for potential application in Alzheimer’s disease (AD) treatment. |
Targets&IC50 | GSK-3β (human):12 nM (IC50) |
In vitro | SAR502250 (0.01-1 μM; 36 h) mitigates Aβ25-35-induced cell death in rat embryonic hippocampal neurons[2]. |
In vivo | SAR502250, administered in varying dosages and methods, exhibits several notable effects in transgenic mice: it attenuates tau hyperphosphorylation in the cortex and spinal cord (1-100 mg/kg, single p.o.), improves cognitive deficits post-Aβ25-35 infusion (10-30 mg/kg, p.o. once daily for 7 weeks) in APP(SW)/Tau(VLW) mice, increases lever-presses in the IRT bin (49-96s) and reinforced responses (10-30 mg/kg, single p.o.), ameliorates chronic stress-induced coat degradation (30 mg/kg, i.p. once daily for 28 days), and decreases psychostimulant-induced hyperactivity (10-60 mg/kg, single p.o.)[2]. |
Molecular Weight | 367.38 |
Formula | C19H18FN5O2 |
Cas No. | 503860-57-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 100 mg/mL (272.20 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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