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CORM-401
🥰Excellent
Catalog No. T14999Cas No. 1001015-18-4
CORM-401 is an oxidant-sensitive CO-releasing molecule used in the research of oxidative stress-mediated pathologies and inflammation [inflammatory].
CORM-401
🥰Excellent
Catalog No. T14999Cas No. 1001015-18-4
CORM-401 is an oxidant-sensitive CO-releasing molecule used in the research of oxidative stress-mediated pathologies and inflammation [inflammatory].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | 43 € | In Stock | |
| 5 mg | 68 € | In Stock | |
| 10 mg | 93 € | In Stock | |
| 25 mg | 159 € | In Stock | |
| 50 mg | 234 € | In Stock | |
| 100 mg | 346 € | In Stock | |
| 1 mL x 10 mM (in DMSO) | 77 € | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | CORM-401 is an oxidant-sensitive CO-releasing molecule used in the research of oxidative stress-mediated pathologies and inflammation [inflammatory]. |
| In vitro | CORM-401 (0.5, 1 mM) induces a sustained increase in the oxygen consumption rate of endothelial EA.hy926 cells; CORM-401 (10, 30, 100 μM) induces a concentration-dependent increase in OCR while reducing ECAR [2]; CORM-401 ( 50 μM; 1 h) significantly reduces ROS generation and cell death induced by TNF-α/CHX and H2O2 [3]; CORM-401 (10, 30, 100 μM) induces a concentration-dependent increase in OCR, while reducing ECAR, while CORM-401 (100 μM; 1 h) induces NO production in endothelial EA.hy926 cells. In addition, CORM-401 (30 μM) induces peak calcium signals and enhances the coupling of endoplasmic reticulum and plasma membrane storage calcium channels [4]. |
| Molecular Weight | 331.2 |
| Formula | C8H6MnNO6S2 |
| Cas No. | 1001015-18-4 |
| Smiles | [H+].O#C[Mn+]1(C#O)(C#O)(C#O)[S]=C([S-]1)N(C)CC(=O)[O-] |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 15 mg/mL (45.29 mM), Sonication is recommended.  H2O: < 1 mg/mL (Insoluble) | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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